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The Role of Phagocytosis in the Production of Endogenous Pyrogen by Polymorphonuclear Leukocytes

  • R. H. Mitchell
  • G. W. Gander
  • F. Goodale
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)

Abstract

In 1948 Beeson (3) reported that granulocytes contain an endogenous pyrogen, which was later (4,5) shown to differ from the pyrogenic endotoxin of gram negative bacteria. Considerable work on the pathogenesis of fever by several investigators eventually yielded an experimental model for it (Fig. 1).

Keywords

Latex Particle Buffy Coat Liver Slice Phagocytic Ability Brain Heart Infusion Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • R. H. Mitchell
    • 1
  • G. W. Gander
    • 1
  • F. Goodale
    • 1
  1. 1.Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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