The Role of Phagocytosis in the Production of Endogenous Pyrogen by Polymorphonuclear Leukocytes
In 1948 Beeson (3) reported that granulocytes contain an endogenous pyrogen, which was later (4,5) shown to differ from the pyrogenic endotoxin of gram negative bacteria. Considerable work on the pathogenesis of fever by several investigators eventually yielded an experimental model for it (Fig. 1).
KeywordsLatex Particle Buffy Coat Liver Slice Phagocytic Ability Brain Heart Infusion Medium
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