Phagocytosis and Intralysosomal Digestion of Subcellular Organelles by Kupffer Cells of Rat Liver
During recent years much interest has been focused on autophagocytosis as a mechanism for degradation of subcellular organelles (4). Some controversy exists in the literature as to what extent or even if autophagocytosis at all is of any importance as a means for cells in physiological conditions to eliminate “worn out” membranes (11). There seems to be little doubt that autophagocytosis is of great importance in sublethal injury and that it is an inducible phenomenon which is increased by glucagon and cyclic AMP (1,3). In earlier work (5,6,8) an experimental model was used in which cellular organelles were introduced to the lysosomal apparatus of Kupffer cells by means of heterophagocytosis. This model was set up to evaluate the capacity of lysosomes to degrade intracellular membranes.
KeywordsKupffer Cell Cell Organelle Microsomal Membrane Subcellular Organelle Residual Body
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