Advertisement

Genetic Regulation of Macrophage Functions

  • D. Mouton
  • Y. Bouthillier
  • A. M. Heumann
  • C. Stiffel
  • G. Biozzi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)

Abstract

Macrophages are characterized by a high capacity of phagocytosis of foreign particles. The engulfed material is then submitted to the rich enzyme equipment contained in their phagosomes. These cells have, thus, a crucial role in both non-specific and specific immunity. Phagocytosis and bactericidal power are the bases of non-specific defence, while uptake and processing of antigens are the first steps of the complex cell interactions constituting the specific immune responses. The two mechanisms may operate synergically since, for example, opsonins specific antibodies increase the rate of bacterial phagocytosis. Furthermore, other mediators, such as MIF, specifically released by lymphocytes, modify different macrophage functions.

Keywords

Phagocytic Activity Selective Breeding Macrophage Function Sheep Erythrocyte Phagocytic Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Biozzi, G., Stiffel, C., Mouton, D., Bouthillier, Y. and Decreusefond, C., Ann. Immunol., 125 C (1974) 107.Google Scholar
  2. 2.
    Mouton, D., Bouthillier, Y., Feingold, N., Feingold, J., Decreusefond, C., Stiffel, C. and Biozzi, G., J. Exp. Med., 141 (1975) 306.PubMedCrossRefGoogle Scholar
  3. 3.
    Stiffel, C., Biozzi, G. and Mouton, D., Mononuclear Phagocytes (Ed. R. van Furth ), Blackwell, Oxford (1970) 335.Google Scholar
  4. 4.
    Stiffel, C., Mouton, D., Bouthillier, Y., Decreusefond, C. and Biozzi, G., J. Reticuloendothel. Soc., 3 (1966) 439.Google Scholar
  5. 5.
    Stiffel, C., Mouton, D., Bouthillier, Y., Decreusefond, C. and Biozzi, G., J. Reticuloendothel. Soc., 7 (1970) 280.Google Scholar
  6. 6.
    Stiffel, C., Mouton, D., Bouthillier, Y., Heumann, A.M., Decreusefond, C., Mevel, J.C. and Biozzi, G., Progress in Immunology (Ed. L. Brent and J. Holborow ), North Holland, Amsterdam, II (1974) 203.Google Scholar
  7. 7.
    Wiener, E. and Bandieri, A., Eur. J. Immunol., 4 (1974) 457.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • D. Mouton
    • 1
  • Y. Bouthillier
    • 1
  • A. M. Heumann
    • 1
  • C. Stiffel
    • 1
  • G. Biozzi
    • 1
  1. 1.Institut Du RadiumFondation CurieParis 5eFrance

Personalised recommendations