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Cyclic Nucleotide Metabolism of Reticuloendothelial Cells

  • C. W. Parker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)

Abstract

There are a number of levels at which cyclic AMP might and apparently does function in the modulation of immunologic inflammation (30,33):
  1. 1.

    In the response of lymphocytic cells to antigen, both in the stimulation of primary and secondary immune responses, and in the induction of lymphocyte mediated cytolysis;

     
  2. 2.

    In the release of mediators of immediate and delayed hypersensitivity (histamine, SRS-A, serotonin, ECF-A, heparin, MIF, prostaglandins, lysosomal enzymes, lymphotoxin) from mast cells, lymphocytes and professional phagocytes;

     
  3. 3.

    In responses of leukocytes, monocytes and other cells to phagocytic and chemotactic stimuli;

     
  4. 4.

    In the responses of smooth muscles, small blood vessels and lymphoid cells to mediators of immediate and delayed hypersensitivity;

     
  5. 5.

    In the differentiation of immunologically immature precursor cells to immunocompetent cells capable of being stimulated by antigen;

     
  6. 6.

    In secondary events in immunological inflammation such as platelet aggregation or in interactions of lymphocytes with one another and with other cell types.

     

Keywords

Mast Cell Adenylate Cyclase Wheat Germ Agglutinin Secondary Immune Response Aminoisobutyric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Adair, W. and Kornfeld, S., J. Biol. Chem., 249 (1974) 496.Google Scholar
  2. 2.
    Alford, R.H., J. Immunol., 104 (1970) 698.PubMedGoogle Scholar
  3. 3.
    Atkinson, J.P., Wedner, H.J. and Parker, C.W., J. Immunol., in press.Google Scholar
  4. 4.
    Bloom, F.E., Wedner, H.J. and Parker, C.W., Pharmacologie Reviews, 25 (1973) 343.Google Scholar
  5. 5.
    Conrad, D.H. and Froese, A., Fed. Proc., 34 (1975) 1001.Google Scholar
  6. 6.
    Cross, M.E. and Orr, M.G., Biochem. J., 124 (1971) 241.PubMedGoogle Scholar
  7. 7.
    Durham, A.C.H., Cell, 2 (1974) 123.PubMedCrossRefGoogle Scholar
  8. 8.
    Gamow, E. and Barnes, F.S., Exp. Cell Res., 87 (1974) 1.PubMedCrossRefGoogle Scholar
  9. 9.
    Gillespie, E., Experientia, 29 (1973) 447.PubMedCrossRefGoogle Scholar
  10. 10.
    Greene, W.C. and Parker, C.W., Biochem. Biophys. Res. Communications, 65 (1975) 456.CrossRefGoogle Scholar
  11. 11.
    Greene, W.C., Parker, C.M. and Parker, C.W., Clin. Res., 23 (1975) 410.Google Scholar
  12. 12.
    Greene, W.C., Parker, C.M. and Parker, C.W., Fed. Proc., 34 (1975) 1029.Google Scholar
  13. 13.
    Greene, W.C., Parker, C.M. and Parker, C.W., in preparation.Google Scholar
  14. 14.
    Greene, W.C., Wedner, H.J. and Parker, C.W., 10th Leucocyte Culture Conf. ( V. Eyszoogel, Conf. Chm. ), Amsterdam, September 1975, in preparation.Google Scholar
  15. 15.
    Hadden, J.W., Haddon, E. and Goldberg, N.D., Cyclic AMP, Cell Growth and the Immune Response (Ed. W. Braun, C.W. Parker and L.M. Lichtenstein ), Springer-Verlag, New York (1973) 237.Google Scholar
  16. 16.
    Hill, H.R., Estensen, R.D., Quie, P.G., Hogan, N.A. and Goldberg, N.D., Metabolism, 24 (1975) 447.PubMedCrossRefGoogle Scholar
  17. 17.
    Hirschhorn, R., Grossman, J. and Weissmann, G., Proc. Soc. Exp. Biol., 133 (1970) 1361.Google Scholar
  18. 18.
    Ignarro, L.J. and George, W.J., Proc. Natl. Acad. Sci. (USA), 71 (1974) 2027.Google Scholar
  19. 19.
    Jakschik, B.A., Kulczycki, A., Sullivan, T.J. and Parker, C.W., in preparation.Google Scholar
  20. 20.
    Kulczycki, A., Isersky, C. and Metzger, H., J. Exp. Med., 139 (1974) 600.PubMedCrossRefGoogle Scholar
  21. 21.
    Kulczycki, A. and Parker, C.W., in preparation.Google Scholar
  22. 22.
    Lewis, R.A., Goetzl, E.J., Wasserman, S.I., Valone, F., Rubin, R. and Austen, K.F., J. Immunol., 114 (1975) 87.PubMedGoogle Scholar
  23. 23.
    Lichtenstein, L.M. and Margolis, S., Science, 161 (1968) 902.PubMedCrossRefGoogle Scholar
  24. 24.
    Lin, S., Santi, D. and Spudich, J., J. Biol. Chem., 249 (1974) 2268.Google Scholar
  25. 25.
    Luckasen, J.R., White, J.G. and Kersey, J.H., Proc. Natl. Acad. Sci. (USA), 71 (1974) 5088.CrossRefGoogle Scholar
  26. 26.
    Lyle, L.R. and Parker, C.W., Biochemistry, 13 (1974) 5415.PubMedCrossRefGoogle Scholar
  27. 27.
    Maino, V.C., Green, N.M. and Crumpton, M.J., Nature, 251 (1974) 324.PubMedCrossRefGoogle Scholar
  28. 28.
    Manganiello, V., Murad, F. and Vaughan, M., J. Biol. Chem., 246 (1971) 2195.Google Scholar
  29. 29.
    Orange, R.P., Austen, W.G. and Austen, K.F., J. Exp. Med., 134 (1971) 1365.Google Scholar
  30. 30.
    Parker, C.W., Inflammation: Mechanics and Control (Ed. I.H. Lepow and P.A. Ward ), Academic Press, New York (1972) 239.Google Scholar
  31. 31.
    Parker, C.W., Biochem. Biophys. Res. Communications, 61 (1974) 1180.Google Scholar
  32. 32.
    Parker, C.W., McDonald, H. and Greene, W.C., in preparation.Google Scholar
  33. 33.
    Parker, C.W., Sullivan, T.J. and Wedner, H.J., Advances in Cyclic Nucleotide Research (Ed. P. Greengard and G.A. Robison), Raven Press, New York, Vol. 4 (1974) 1.Google Scholar
  34. 34.
    Sage, H., personal communication.Google Scholar
  35. 35.
    Schultz, G., Hardman, J.G., Schultz, K., Baird, C.E. and Sutherland, E.W., Proc. Natl. Acad. Sci. (USA), 70 (1973) 3889.CrossRefGoogle Scholar
  36. 36.
    Sela, B., Wang, J.L. and Edelman, G.M., Proc. Natl. Acad. Sci. (USA), 72 (1975) 1127.Google Scholar
  37. 37.
    Smith, J.W., Steiner, A.L., Newberry, W.M. and Parker, C.W., J. Clin. Invest., 50 (1971) 432.PubMedCrossRefGoogle Scholar
  38. 38.
    Smith, J.W., Steiner, A.L. and Parker, C.W., J. Clin. Invest., 50 (1971) 442.PubMedCrossRefGoogle Scholar
  39. 39.
    Smith, R.J. and Ignarro, L.J., Proc. Natl. Acad. Sci. (USA), 72 (1975) 108.CrossRefGoogle Scholar
  40. 40.
    Sullivan, T.J., Brown, L. and Parker, C.W., unpublished data.Google Scholar
  41. 41.
    Sullivan, T.J. and Parker, C.W., Biochem. Biophys. Res. Communications, 55 (1973) 1334.Google Scholar
  42. 42.
    Sullivan, T.J., Parker, K.L., Eisen, S.E. and Parker, C.W., J. Immunol., 114 (1975) 1480.Google Scholar
  43. 43.
    Sullivan, T.J., Parker, K.L., Kulczycki, A. and Parker. C.W. in preparation.Google Scholar
  44. 44.
    Wang, J.L., McLain, D.A. and Edelman, G.M., Proc. Natl. Acad. Sci. (USA), 72 (1975) 1917.Google Scholar
  45. 45.
    Watson, J., J. Exp. Med., 141 (1975) 97.PubMedCrossRefGoogle Scholar
  46. 46.
    Wedner, H.J., Dankner, R. and Parker, C.W., J. Immunol., in press.Google Scholar
  47. 47.
    Wedner, H.J. and Parker, C.W., Biochem. Biophys. Res. Communications, 62 (1975) 808.CrossRefGoogle Scholar
  48. 48.
    Weinstein, Y., Chambers, D.A., Bourne, H.R. and Melmon, K.L., Nature, 251 (1974) 352.PubMedCrossRefGoogle Scholar
  49. 49.
    Weissmann, G., Dukor, P. and Zurier, R.B., Nature (New Biology), 231 (1971) 131.Google Scholar
  50. 50.
    Whitney, R.B. and Sutherland, R.M., Biochim. Biophys. Acta, 298 (1973) 790.CrossRefGoogle Scholar
  51. 51.
    Wray, V.P. and Walborg, E.F., Cancer Res., 31 (1971) 2072.PubMedGoogle Scholar
  52. 52.
    Zurier, R.B., Tynant, N. and Weissmann, G., Fed. Proc., 32 (1973) 744.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • C. W. Parker
    • 1
  1. 1.Washington University School of MedicineSt. LouisUSA

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