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Regulation of Xanthine Dehydrogenase and Purine Nucleoside Phosphorylase Levels in Chick Liver

  • J. R. Fisher
  • W. D. Woodward
  • P. C. Lee
  • J. Wu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41A)

Abstract

A number of agents which have been shown to affect the levels of xanthine dehydrogenase (XDH) and purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) in the liver of the chick are listed in Table I. We have divided these agents into four groups depending upon which enzymes are affected coordinately. Group A agents induce increases in the levels of XDH, PNP and probably other enzymes involved in purine synthesis. So far Group B agents appear to specifically act on XDH, although studies of other enzymes may reveal additional effects. Group C contains representative steroid hormones which induce or suppress levels of XDH and in one case (hydrocortisone) induces an increase in tyrosine transaminase. Group D contains unsaturated fatty acids including oleic, linoleic and linolenic acids. These agents suppress levels of XDH and PNP.

Keywords

Oleic Acid High Dietary Protein Purine Nucleoside Phosphorylase Xanthine Dehydrogenase Purine Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • J. R. Fisher
    • 1
  • W. D. Woodward
    • 1
  • P. C. Lee
    • 1
  • J. Wu
    • 1
  1. 1.Dept. of Chemistry and Inst. of Molec. Biophys.Florida State Univ.TallahasseeUSA

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