Human Glutamine Phosphoribosylpyrophosphate (PP-ribose-P) Amidotransferase: Kinetic, Regulation and Configurational Changes
In a large percentage of patients with gout, hyperuricemia is the result of an increase in the rate of purine biosynthesis de novo (Wyngaarden and Kelley, 1972). Consequently, it is important to understand the molecular basis for the regulation of purine biosynthesis in man.
KeywordsEnzyme Preparation Sucrose Gradient Large Form Small Form Sedimentation Coefficient
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