Genetic Control of Bacterial Purine Phosphoribosyltransferases and an Approach to Gene Enrichment

  • Joseph S. Gots
  • Charles E. Benson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41A)


Enteric bacteria such as Escherichia coli and Salmonella typhimurium possess three separate genes that control three different phosphoribosyltransferases (PRI). A-PRT (apt gene) is active only for adenine; G-PRT (gpt gene) converts guanine, hypoxanthine and xanthine; and H-PRT (hpt gene) is primarily active for hypoxanthine, poorly for guanine and not at all for xanthine.


Elution Pattern Cesium Chloride Strain TM445 Cellulose Column Chromatography Cesium Chloride Density Gradient 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Joseph S. Gots
    • 1
  • Charles E. Benson
    • 1
  1. 1.University of PennsylvaniaPhiladelphiaUSA

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