Studies on Metabolic Cooperation Using Different Types of Normal and Hypoxanthine-Guanine Phosphoribosyltransferase (HG-PRT) Deficient Cells

  • T. L. Oei
  • C. H. M. M. de Bruyn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41A)


The experiments reported in this paper were designed to test one of several possible mechanisms that may underly the phenomenon of metabolic cooperation between normal and HG-PRT deficient cells, namely transfer of some intermediate of the purine metabolism from cell to cell.


Deficient Cell Purine Metabolism Radioactive Label Normal Lymphocyte Cell Membrane Fraction 
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    H. Subak-Sharpe, R.R. Bark and J.D. Pitts (1966): nMetabolic cooperation by cell to cell transfer between genetically different mammalian cells in tissue culture. Heredity 21, 342–343.Google Scholar
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    H. Subak-Sharpe, R.R. Bark and J.D. Pitts (1969): Metabolic cooperation between biochemically marked mammalian cells in tissue culture. J. Cell Sci. 4, 353–367.PubMedGoogle Scholar
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    C.H.M.M. de Bruyn and T.L. Oei (1973): Purine metabolism in intact erythrocytes from controls and HG-PRT deficient individuals. These Proceedings.Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • T. L. Oei
    • 1
  • C. H. M. M. de Bruyn
    • 1
    • 1
  1. 1.Department of Human Genetics, Faculty of MedicineUniversity of NijmegenThe Netherlands

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