Skip to main content
SpringerLink
Log in

Properties of Erythrocyte Purine Phosphoribosyltransferases in Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency

  • Chapter
Purine Metabolism in Man

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 41A))

Abstract

Partial deficiency of HGPRT, a salvage enzyme of purine metabolism, has been demonstrated to be the primary abnormality causing purine overproduction in a small proportion of patients with gout (1–4). The quantitative deviation in the activity of this enzyme has been shown by Kelley et al. to be associated with decreased stability to thermal inactivation (2). These authors suggest that in the affected subjects HGPRT is structurally altered. Furthermore, in some of these patients erythrocyte adenine phosphoribosyltransferase (APRT) activity was found to be increased and relatively thermostable (2).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kelley W.N., Rosenbloom F.M., Henderson J.F. and Seegmiller J.E. Proc. nat. Acad. Sci. (Wash.) 57: 1735, 1967.

    Article  CAS  Google Scholar 

  2. Kelley W.N., Greene M.I., Rosenbloom F.M., Henderson J.F. and Seegmiller J.E. Ann. intern. Med. 70: 155, 1969.

    PubMed  CAS  Google Scholar 

  3. Kogut M.D., Donnell G.N., Nyhan W.I. and Sweetman I. Amer. J. Med. 48: 148, 1970.

    Article  PubMed  CAS  Google Scholar 

  4. Sperling O., Frank M., Ophir R., Liberman U.A., Adam A. and De Vries A. Europ. J. clin. biol. Res. 15: 942, 1970.

    CAS  Google Scholar 

  5. Greene M.L., Bayles J.R. and Seegmiller J.E. Science 167: 887, 1970.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Rogoff-Wellcome Medical Research Institute and the Metabolic Unit of Department of Medicine D, Tel-Aviv University Medical School, Beilinson Hospital, Petah Tikva, Israel

    O. Sperling, P. Boer & A. de Vries

Authors
  1. O. Sperling
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Boer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. de Vries
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Metabolic Disease, Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Petah-Tikva, Israel

    Oded Sperling  & Andre De Vries  & 

  2. Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA

    James B. Wyngaarden

Rights and permissions

Reprints and permissions

Copyright information

© 1974 Plenum Press, New York

About this chapter

Cite this chapter

Sperling, O., Boer, P., de Vries, A. (1974). Properties of Erythrocyte Purine Phosphoribosyltransferases in Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency. In: Sperling, O., De Vries, A., Wyngaarden, J.B. (eds) Purine Metabolism in Man. Advances in Experimental Medicine and Biology, vol 41A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3294-7_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3294-7_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3296-1

  • Online ISBN: 978-1-4684-3294-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation