Advertisement

Properties of Erythrocyte Purine Phosphoribosyltransferases in Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency

  • O. Sperling
  • P. Boer
  • A. de Vries
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41A)

Abstract

Partial deficiency of HGPRT, a salvage enzyme of purine metabolism, has been demonstrated to be the primary abnormality causing purine overproduction in a small proportion of patients with gout (1–4). The quantitative deviation in the activity of this enzyme has been shown by Kelley et al. to be associated with decreased stability to thermal inactivation (2). These authors suggest that in the affected subjects HGPRT is structurally altered. Furthermore, in some of these patients erythrocyte adenine phosphoribosyltransferase (APRT) activity was found to be increased and relatively thermostable (2).

Keywords

Microcrystalline Cellulose Mutant Enzyme Thermal Inactivation Purine Nucleoside Purine Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kelley W.N., Rosenbloom F.M., Henderson J.F. and Seegmiller J.E. Proc. nat. Acad. Sci. (Wash.) 57: 1735, 1967.CrossRefGoogle Scholar
  2. 2.
    Kelley W.N., Greene M.I., Rosenbloom F.M., Henderson J.F. and Seegmiller J.E. Ann. intern. Med. 70: 155, 1969.PubMedGoogle Scholar
  3. 3.
    Kogut M.D., Donnell G.N., Nyhan W.I. and Sweetman I. Amer. J. Med. 48: 148, 1970.PubMedCrossRefGoogle Scholar
  4. 4.
    Sperling O., Frank M., Ophir R., Liberman U.A., Adam A. and De Vries A. Europ. J. clin. biol. Res. 15: 942, 1970.Google Scholar
  5. 5.
    Greene M.L., Bayles J.R. and Seegmiller J.E. Science 167: 887, 1970.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • O. Sperling
    • 1
  • P. Boer
    • 1
  • A. de Vries
    • 1
  1. 1.Rogoff-Wellcome Medical Research Institute and the Metabolic Unit of Department of Medicine DTel-Aviv University Medical School, Beilinson HospitalPetah TikvaIsrael

Personalised recommendations