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Synthesis of Purine Nucleotides in Human and Leukemic Cells. Interaction of 6-Mercaptopurine and Allopurinol

  • W. Wilmanns
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41A)

Abstract

In proliferating cells purine nucleotides — necessary for DNA- and RNA-synthesis — can be formed by incorporation of small precursors (de novo pathway) and by utilisation of free purin bases (salvage pathway). The most important reactions of both metabolic pathways are demonstrated in figure 1. The first reaction of the de-novo pathway — the formation of phosphoribosylamine from glutamine and phosphoribosylpyrophosphate (PRPP) by the enzyme PRPPamidotransferase — is the target of a negative feed back control mechanism by the endproducts IMP,GMP and AMP (1).

Keywords

Xanthine Oxidase Acute Leukemia Purine Nucleotide Purine Synthesis Purine Ring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • W. Wilmanns
    • 1
  1. 1.Department of Internal Medicine IIUniversity ClinicTuebingenGermany

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