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Purine Salvage in Spleen Cells

  • G. Partsch
  • H. Altmann
  • R. Eberl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41A)

Abstract

Since the discussion livened up again about the formation of nucleotides for DNA-replication and DNA-repair by the contested theory of Werner (1971) it seems important to study the problems of nucleotide formation during repair processes. Our own stu­dies performed with the radiosensitive organism Byssochlamys fulva and the radioresistant Pullularia pullulans led us to suppose that the synthesis of purine nucleoside monophosphates via purinephosphoribosyltransferase (purine-PRT) is not as sensitive to radiation as the de novo synthesis. Therefore a relation between the salvage pathway and nucleotide forma­tion during repair processes does not seem impossible.

Keywords

Spleen Cell Xeroderma Pigmentosum Salvage Pathway Purine Nucleoside Purine Base 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • G. Partsch
    • 1
  • H. Altmann
    • 1
  • R. Eberl
    • 2
  1. 1.Institute of BiologyResearch Centre Seibers­dorfSeibersdorfAustria
  2. 2.II.Med.Department for Rheumatic DiseasesKrankenhaus LainzViennaAustria

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