Purine Salvage in Spleen Cells

  • G. Partsch
  • H. Altmann
  • R. Eberl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41A)


Since the discussion livened up again about the formation of nucleotides for DNA-replication and DNA-repair by the contested theory of Werner (1971) it seems important to study the problems of nucleotide formation during repair processes. Our own stu­dies performed with the radiosensitive organism Byssochlamys fulva and the radioresistant Pullularia pullulans led us to suppose that the synthesis of purine nucleoside monophosphates via purinephosphoribosyltransferase (purine-PRT) is not as sensitive to radiation as the de novo synthesis. Therefore a relation between the salvage pathway and nucleotide forma­tion during repair processes does not seem impossible.


Spleen Cell Xeroderma Pigmentosum Salvage Pathway Purine Nucleoside Purine Base 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • G. Partsch
    • 1
  • H. Altmann
    • 1
  • R. Eberl
    • 2
  1. 1.Institute of BiologyResearch Centre Seibers­dorfSeibersdorfAustria
  2. 2.II.Med.Department for Rheumatic DiseasesKrankenhaus LainzViennaAustria

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