Pharmacological Alterations of Intracellular Phosphoribosylpyrophosphate (PP-ribose-P) in Human Tissues

  • I. H. Fox
  • W. N. Kelley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41A)


Intracellular PP-ribose-P, a ribose sugar with phosphate at the five position and pyrophosphate at the 1 position (Fig. 1), is complexly regulated by a balance between synthesis and degradation. Any alteration in PP-ribose-P concentration may potentially alter the rate of purine biosynthesis de novo since PP-ribose-P is rate limiting for this pathway. Drug induced changes of intracellular PP-ribose-P may in this way substantially alter human purine metabolism.


Nicotinic Acid Methylene Blue Orotic Acid Ehrlich Tumor Ascites Cell Ehrlich Tumor Ascites 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • I. H. Fox
    • 1
    • 2
  • W. N. Kelley
    • 1
    • 2
  1. 1.University of TorontoCanadaUSA
  2. 2.Duke University Medical CenterDurhamUSA

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