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Pharmacological Alterations of Intracellular Phosphoribosylpyrophosphate (PP-ribose-P) in Human Tissues

  • I. H. Fox
  • W. N. Kelley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41A)

Abstract

Intracellular PP-ribose-P, a ribose sugar with phosphate at the five position and pyrophosphate at the 1 position (Fig. 1), is complexly regulated by a balance between synthesis and degradation. Any alteration in PP-ribose-P concentration may potentially alter the rate of purine biosynthesis de novo since PP-ribose-P is rate limiting for this pathway. Drug induced changes of intracellular PP-ribose-P may in this way substantially alter human purine metabolism.

Keywords

Nicotinic Acid Methylene Blue Orotic Acid Ehrlich Tumor Ascites Cell Ehrlich Tumor Ascites 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • I. H. Fox
    • 1
    • 2
  • W. N. Kelley
    • 1
    • 2
  1. 1.University of TorontoCanadaUSA
  2. 2.Duke University Medical CenterDurhamUSA

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