Pharmacological Alterations of Intracellular Phosphoribosylpyrophosphate (PP-ribose-P) in Human Tissues
Intracellular PP-ribose-P, a ribose sugar with phosphate at the five position and pyrophosphate at the 1 position (Fig. 1), is complexly regulated by a balance between synthesis and degradation. Any alteration in PP-ribose-P concentration may potentially alter the rate of purine biosynthesis de novo since PP-ribose-P is rate limiting for this pathway. Drug induced changes of intracellular PP-ribose-P may in this way substantially alter human purine metabolism.
KeywordsNicotinic Acid Methylene Blue Orotic Acid Ehrlich Tumor Ascites Cell Ehrlich Tumor Ascites
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