Regulatory Aspects of the Synthesis of 5-Phosphoribosyl-1-Pyrophosphate in Human Red Blood Cells
It has been established in earlier investigations1,2 that the synthesis of purine nucleotides in mammalian red blood cells (RBC) is governed by the extent of endogenous supply of 5-phosphoribosyl-1-pyrophosphate (PRPP), as an essential intermediary. Consequently, the elucidation of the mechanisms controlling the formation of PRPP within the cell appears to be of crucial importance for the understanding of the overall metabolic regulation of purine nucleotide biosynthesis.
KeywordsRegulatory Aspect Purine Nucleotide Phenazine Methosulfate PRPP Synthetase Endogenous Supply
Unable to display preview. Download preview PDF.
- 2.A. Hershko, Ch. Hershko and J. Mager. Israel J. Med. Sci., 4, 939, (1968).Google Scholar
- 3.J. Mager, A. Dvilansky, A. Razin, E. Wind and G. Izak. Israel J. Med. Sci. 2, 297, (1966).Google Scholar
- 5.R. Benesch, R. E. Benesch and C. D. Yu. Proc. Nat. Acad. Sci. U. S., 59, 531, (1968).Google Scholar