Regulatory Aspects of the Synthesis of 5-Phosphoribosyl-1-Pyrophosphate in Human Red Blood Cells

  • Nira Sciaky
  • A. Razin
  • Bruria Gazit
  • J. Mager
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41A)

Abstract

It has been established in earlier investigations1,2 that the synthesis of purine nucleotides in mammalian red blood cells (RBC) is governed by the extent of endogenous supply of 5-phosphoribosyl-1-pyrophosphate (PRPP), as an essential intermediary. Consequently, the elucidation of the mechanisms controlling the formation of PRPP within the cell appears to be of crucial importance for the understanding of the overall metabolic regulation of purine nucleotide biosynthesis.

Keywords

Adenine Creatine Purine NADP Pentose 

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Nira Sciaky
    • 1
  • A. Razin
    • 1
  • Bruria Gazit
    • 1
  • J. Mager
    • 1
  1. 1.Department of Cellular BiochemistryThe Hebrew University-Hadassah Medical SchoolJerusalemIsrael

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