Redistribution of Cerebrocortical Microflow During Increased Neuronal Activity
It is well established1, that among a wide range of circumstances the cerebral blood flow is tightly coupled via different mechanisms to the metabolic activity of the neuronal tissue in volumes down to several cubic millimeters. Many of these adjusting mechanisms (O2, CO2, H+, K+, metabolites, neurotransmitters, etc.) coexist in tne brain and can be equally influenced in their effectiveness by the distribution pattern of the cerebral intraparenchymal circulation in tissue microareas, which along with these factors will ultimately determine the distribution of blood flow among the smallest groups of neurones in functional integrity at any given functional state of the tissue. Experimental data on high resolution distribution pattern of cerebrocortical microflow in resting conditions and during increased metabolic demand in focal tissue areas, therefore, seems to be important to acquire. A recently accomplished television densitometric method2,3 imaging microf low over the brain cortex has provided the means to study the question outlined above at adequate spatial and temporal resolution in the cat in control conditions and during cold paw stimulation.
KeywordsCerebral Blood Flow Brain Cortex Neuronal Tissue Adjust Mechanism Pixel Data
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