Continuous Non Invasive Monitoring of Human Brain by Near Infrared Spectroscopy

  • M. Ferrari
  • I. Giannini
  • G. Sideri
  • E. Zanette
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


Precise time-and space-resolved measurement of brain energy metabolism and circulation in vivo would provide important information on the cerebral physiology and pathophysiology, Consequently different optoelectronic techniques based on spectroscopic signals of the normoxic-anoxic transition of pyridine nucleotide (NADH), flavoprotein (Fp) and cytochrome-c-oxidase (cyt a,a3) have been developed (Tab. 1). Cyt a,a3 which catalyzes more than 90% of cellular oxygen consumption, has a greater visible absorption in the reduced than in oxidized form; it is characterized by a broad band in the near infrared (I.R.) centered at 830 nm and attributable to the copper component of oxidized enzyme.


Near Infrared Spectroscopy Pyridine Nucleotide Spectral Contribution Brain Energy Metabolism Spectroscopic Signal 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Brunori, M., Antonini, E. and Wilson, M.T. In “Metal ions in biological systems” Ed. H. Siegel 13, p. 187, 1981.Google Scholar
  2. 2.
    Dora, E. J. Neurochem. 42, 101, 1984.PubMedCrossRefGoogle Scholar
  3. 3.
    Fein, J.M. and Olinger, R. Neurosurgery 10, 428, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Ferrari, M., Giannini, I., Carpi, A. and Fasella, P. Physiol. Chem. Phys. and medical NMR 15, 107, 1983.Google Scholar
  5. 5.
    Ferrari, M., Giannini, I., Carpi, A., Fasella, P., Fieschi, C. and Zanette, E. In “Angiology” p. 299, Ed. P. Balas, Plenum Publishing Co, London, 1984.Google Scholar
  6. 6.
    Fox, E.J., Harmel, M.H., Mitnick, M.H. and Jöbsis, F.F. Anesthesiology, 57, A160, 1982.CrossRefGoogle Scholar
  7. 7.
    Franke, H., Barlow, C.H. and Chance, B. Am. J. Physiol. 231, 1082, 1976.PubMedGoogle Scholar
  8. 8.
    Franke, H., Barlow, C.H. and Chance, B. Int. J. Biochem. 12, 269, 1980.PubMedCrossRefGoogle Scholar
  9. 9.
    Giannini, I., Ferrari, M., Carpi, A. and Fasella, P. Physiol. Chem. Phys. 14, 295, 1982.PubMedGoogle Scholar
  10. 10.
    Hassinen, I.E., Hiltunen, J.K. and Takala, T.E.S. Cardiovas. Res. 15, 86, 1981.CrossRefGoogle Scholar
  11. 11.
    Ji, S., Lemaster, J.J. and Thurman, R.G. FEBS Letters 113, 37, 1980.PubMedCrossRefGoogle Scholar
  12. 12.
    Jöbsis, F.F., Keizer, J.H., La Manna, J.C. and Rosenthal, M. J. App. Physiol. 43, 858, 1977.Google Scholar
  13. 13.
    Jöbsis, F.F. Science 198, 1264, 1977.PubMedCrossRefGoogle Scholar
  14. 14.
    Kimura, S., Suzaki, T., Kobayaski, S., Abe, K. and Ogata, E. Biochem. Biophys. Res. Com. 119, 212, 1984.PubMedCrossRefGoogle Scholar
  15. 15.
    Masters, B.R., Chance, B. and Fischbarg, J. TIBS 6, 282, 1981.Google Scholar
  16. 16.
    Masters, B.R. Curr. Eye Res. 3, 23, 1984.PubMedCrossRefGoogle Scholar
  17. 17.
    Mayevsky, A., Zarchin, N., Kaplan, H., Haveri, J., Haselgroove, J. and Change, B. Brain Res. 267, 95, 1983.CrossRefGoogle Scholar
  18. 18.
    Mayevsky, A. Brain Res. Rew. 7, 49, 1984.Google Scholar
  19. 19.
    Makino, N., Kanaide, H., Yoshimura, R. and Nakamura, M. Am. J. Physiol. 245, H237, 1983.Google Scholar
  20. 20.
    Takatani, S., Cheung, P.W. and Ernst, E.A. Annals Biomed. Eng. 8, 1, 1980.CrossRefGoogle Scholar
  21. 21.
    Wimberley, P.D., Pedersen, K.G., Thode, J., Fogh-Andersen, N., Sørensen, A.M. and Siggaard-Andersen, N. Clin. Chem. 29, 1471, 1983.PubMedGoogle Scholar
  22. 22.
    Wodick, R., and Lübbers, D.W. Hoppe-Seyler’s Z. Physiol. Chem. 355, 583, 1974.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • M. Ferrari
    • 1
  • I. Giannini
    • 2
  • G. Sideri
    • 3
  • E. Zanette
    • 3
  1. 1.Laboratorio di Fisiopatologia di Organo e di SistemaIstituto Superiore di SanitàRomaItalia
  2. 2.ASSORENIMonterotondo, RomaItalia
  3. 3.Dipartimento di Scienze NeurologicheUniversità “La Sapienza” RomaItalia

Personalised recommendations