Near Infrared Optical Monitoring of Intact Skeletal Muscle During Hypoxia and Hemorrhagic Hypotension in Cats
Pathophysiologic states associated with decreased arterial oxygen delivery are often accompanied by fractional redistribution of cardiac output (1,2). Such responses, mediated in part by chemo or baroreceptor reflexes, divert oxygen flow away from resting tissues such as splanchnic viscera or skeletal muscle and towards more hypoxia-ischemia sensitive tissues such as brain. The feasibility of using non-invasive, near infrared (NIR) multiple wavelength optical assessment of skeletal muscle metabolism as a sensitive and early indicator of progressive O2 insufficiency during physiological conditions associated with blood flow redistribution was investigated in anesthetized, paralyzed cats. Optically derived NIR cytochrome a,a 3 oxidation-reduction responses were recorded continuously and together with combined oxygen-labile optical density changes in capillary blood and myoglobin saturation during controlled protocols of hypoxic hypoxia or hemorrhagic hypotension and recovery.
KeywordsClearance Curve Shed Blood Hypoxic Hypoxia Skeletal Muscle Metabolism Alveolar Hypoxia
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