The Behaviour of the Tissue pO2 in Transparent Chambers of Rats with and Without Tumour Implantations

  • P. Streichhan
  • M. Fischer
  • H. Acker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


Tissue oxygen partial pressure (PtO2 reflects O2 supply and O2 consumption of an organ and, hence, has characteristic values in active biological systems (Lubbers, 1981ar 1981b; Kessler et al., 1984). Restorations of an organ-specific O2 supply after injuries have often been examined, since recovery of O2 supply is important for the survival of tissue either in natural wounds or clinical surgery (Hunt, 1970, 1973; Hunt et al., 1966, 1972a, 1972b; Goodwin and Heppenstall, 1978; Silver, 1978, Winter, 1978). In order to follow structural and functional changes in wounds simultaneously, recent experimental work in wound healing of subcutaneous tissue was often done by intra-vitalmicroscopy in transparent chambers (van den Brenk, 1956; Endrich et al., 1982). This report deals with the healing of chronic subcutis wounds in dorsal rat skinfolds covered by transparent chambers (TK) (Streichhan and Lübbers, 1982). It is confined to PtO2 changes as a function of post-operative age in acute normoxic, hypoxic, and post-hypoxic breathing conditions. Modulations of PtO2 under the different conditions by heteroplastic tumour implantations were investigated as a further parameter.


Tumour Implantation Tumour Spheroid Transparent Chamber Tissue Pocket Tissue Oxygen Partial Pressure 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • P. Streichhan
    • 1
  • M. Fischer
    • 2
  • H. Acker
    • 1
  1. 1.Max-Planck-Institut für SystemphysiologieDortmundGermany
  2. 2.Physiologisches Institut IIUniversität (Neurophysiologie)BonnGermany

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