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Glucose, Lactate, and Ketone Body Utilization by Human Mammary Carcinomas in Vivo

  • F. Kallinowskil
  • S. Davel
  • P. Vaupell
  • K. H. Baessler
  • K. Wagner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)

Abstract

Uncontrolled growth, one of the fundamental properties of malignant tumors, requires a great supply of energy. This energy can be derived from the use of a variety of substrates. Besides glucose oxidation and glucose breakdown to lactic acid, the turnover of endogeneous substrates such as amino acids, free fatty acids and ketone bodies is well documented in vitro. However, under in vivo conditions, only glucose utilization has been investigated in detail, using tumor isotransplants in rodents. For human tumors, only scarce data is available, derived mainly from clinical observations rather than from systematic studies.

Keywords

Ketone Body Tumor Blood Flow Glucose Uptake Rate Glucose Availability Lactic Acid Output 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • F. Kallinowskil
    • 1
  • S. Davel
    • 1
  • P. Vaupell
    • 1
  • K. H. Baessler
    • 2
  • K. Wagner
    • 2
  1. 1.Dept. Applied PhysiologyUniversity of MainzMainzGermany
  2. 2.Dept. Physiol. ChemistryUniversity of MainzMainzGermany

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