Blood Flow and Oxygen Supply to Human Mammary Carcinomas Transplanted into Nude Rats

  • S. Dave
  • F. Kallinowski
  • P. Vaupel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


Tumor blood flow (TBF), by itself, greatly influences the efficiency of nonsurgical therapeutic modalities, especially chemotherapy and hyperthermia. Furthermore, TBF is one of the most important determinants of tumor tissue oxygenation in vivo, thus playing a relevant role in tumor growth kinetics and in the development of regressive changes. In addition, the oxygenation of tumor tissue strongly determines the efficiency of radiation therapy and to a certain extent, pharmacodynamics of some antiproliferative drugs. Despite the considerable information available for rodent tumor systems, there are only sporadic ireports on blood flow (Beaney et al., 1984, Johnson, 1976, Mäntylä, 1979, Mäntylä et al., 1982) and oxygen supply (Beaney et al., 1984, Müller- Klieser et al., 1981) in human tumors mostly derived from clinical observations rather than from systematic studies. Therefore, using an epigastric pouching technique in immune- deficient (rnu/rnu) rats, TBF and oxygen utilization were evaluated systematically in tissue- isolated human mammary tumor heterotransplants.


Consumption Rate Mammary Carcinoma Mean Arterial Blood Pressure Oxygen Consumption Rate Regional Blood Flow 
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  1. Betke, K., and Savelsberg, W., 1950, Stufenphotometrische Hämoglobinbestimmung mittels Cyanhämiglobinf Biochem. Zschr., 320: 431.Google Scholar
  2. Beaney, R.P., Lammertsma, A.A., Jones, T., McKenzie, C., and Hainan, K.E., 1984, Positron emission tomography for in vivo measurement of regional blood flow, oxygen utilization and blood volume in patients with breast carcinoma, Lancet, 1: 131.PubMedCrossRefGoogle Scholar
  3. Bork, R., Vaupel, P., Günther, H., and Thews, G., 1975, Atemgas- pH- Nomogramme für das Rattenblut bei 37°C, Anaesthesist, 24: 84.PubMedGoogle Scholar
  4. Constable, T.B., Rogers, M.A., and Evans, N.T.S., 1978, Comparison between the oxygen removal rate and the histological structure of normal and tumor tissues, Pflügers Arch., 373: 145.PubMedCrossRefGoogle Scholar
  5. Gullino, P.M., Grantham, F.H., and Courtney, A.H., 1967, Utilization of oxygen by transplanted tumors in vivo, Cancer Res., 27: 1020.PubMedGoogle Scholar
  6. Johnson, R., 1976, A thermodynamic method for investigation of radiation induced changes in the microcirculation of human tumors, Int. J. Radiat. Oncol. Biol. Phys., 1: 659.PubMedCrossRefGoogle Scholar
  7. Mäntylä, M.J., 1979, Regional blood flow in human tumors, Cancer Res., 39: 2304.PubMedGoogle Scholar
  8. Mäntylä, M.J., Toivanen, J.T., Pitkänen, M.A., and Rekonen, A.H., 1982, Radiation- induced changes in regional blood flow in human tumors, Int. J. Radiat. Oncol. Biol. Phys., 8: 1711.PubMedCrossRefGoogle Scholar
  9. Müller- Klieser, W., Vaupel, P., Manz, R., and Schmid-seder, R., 1981, Intracapillary oxyhemoglobin saturation of malignant tumors in human, Int. J. Radiat. Oncol. Biol. Phys., 7: 1397.Google Scholar
  10. Sauer, L.A., Stayman, J.W., and Dauchy, R.T., 1982, Amino acid, glucose, and lactic acid utilization in vivo by rat tumors, Cancer Res., 42: 4090.PubMedGoogle Scholar
  11. Vaupel P., 1977, Hypoxia in neoplastic tissue, Microvasc. Res., 13: 399.PubMedCrossRefGoogle Scholar
  12. Vaupel P., 1982, Pathophysiologie der Durchblutung maligner Tumoren, Funktionsanalyse biolog. Syst., 8: 155.Google Scholar
  13. Vaupel, P., Frinak, S., and Bicher, H.I., 1981, Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma, Cancer Res., 41: 2008.PubMedGoogle Scholar
  14. Vaupel, P., Kallinowski, F., Dave, S., Gabbert, H., and Bastert, G., 1985, Human mammary carcinomas in nude rats — a new approach for investigating oxygen transport and substrate utilization in tumor tissues, Advanc. Exptl. Med. Biol., in press.Google Scholar
  15. Zander, R., 1981, Oxygen solubility in normal human blood, Advanc. Physiol. Sci., 25: 331.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • S. Dave
    • 1
  • F. Kallinowski
    • 1
  • P. Vaupel
    • 1
  1. 1.Dept. Applied PhysiologyUniversity of MainzMainzW.- Germany

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