Membrane Potential and Ca Influx in Hypoxic and Normoxic Carotid Body Type-I Cells

  • F. Pietruschka
  • A. Acker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


The carotid body is described as being a chemoreceptor since 1928 (de Castro). Under hypoxia, the natural stimulus, transmitter like dopamine, and Ach are released (Fidone et al., 1982; Eyzaguirre et al., 1965) and chemoreceptor discharge is increased (Delpiano and Acker, 1980). Till now it is not clear, whether this chemoreceptive process is located in the glomus cell membrane or in the adjacent nerve endings. Working with cells in primary tissue culture we can investigate the stimulation process on isolated carotid body cells. As previous studies showed (Pietruschka and Schäfer, 1976) fine structure of these cells, especially the dense cored vesicles, is preserved in culture.


Glioma Cell Calcium Influx Carotid Body Dense Core Vesicle Glomus Cell 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • F. Pietruschka
    • 1
  • A. Acker
    • 1
  1. 1.Max-Planck-Institut für SystemphysiologieDortmundGermany

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