Extracellular pH Responses to Different Stimuli in the Superfused Cat Carotid Body
The superfused carotid body responds to a PO2 decrease or a PCO2 increase in the superfusion medium with an increase of the chemosensory activity of the sinus nerve. Although many hypotheses have tried to give an adequate explanation, the intrinsic mechanism of the chemoreception has not been elucidated. Among these hypotheses (for review see Belmonte and Gonzalez, 1983), the metabolic hypothesis originating from the Russian school (Anichkov and Belen’kii, 1963) has yielded strong evidence for a linkage between chemoreception and the metabolic energy production in the last years (Joels and Neil, 1963, 1968; Krylov and Anichkov, 1968; Mulligan and Lahiri, 1981; Mulligan et al., 1981). Perturbation of mitochondrial respiration and energy metabolism produced by a PO2 decrease could be responsible for the neurohumoral secretion from cells, that at last creates chemoreception (Mills and Jöbsis, 1972; Purves, 1970). The implication of the glycolytic pathway in this hypothesis was never seriously considered, since most of the experimental evidence is based on blockers of the mitochondrial respiratory chain and uncouplers of the oxidative phosphorylation (Anichkov and Belen’kii, 1963).
KeywordsCarotid Body Nerve Response Chemosensory Response Normal Glucose Concentration Chemoreceptor Activity
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