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Influence of Portocaval Anastomosis (PCA) on Tissue PO2 of Renal Cortex and Skeletal Muscle In Rats With Liver Cirrhosis

  • T. Brendler
  • R. Heinrich
  • S. Dette
  • M. Günderoth-Palmowski
  • M. Grein
  • E. Huber
  • W. Grauer
  • W. Fleckenstein
  • H. Schomerus
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)

Abstract

Portocaval anastomosis in the rat leads to a time-limited hyper-perfusion of the skeletal muscle due to an increase of cardiac output. Although it is known that PCA in rats changes intrarenal perfusion to dimished relative cortical perfusion (Grün et al., 1976) resembling cirrhosis-induced perfusion changes in man (Kew et al., 1971), there is no influence on PO2 distribution and mean tissue PO2 on the renal cortex (Grein et al,, 1984). Pharmacologically induced liver cirrhosis with spontaneous portal hypertension and consecutive portosystemic shunting in rats also leads to an increase of mean muscular PO2 but mean PO2 on the renal cortex declines (Dette et al., 1984).

Keywords

Skeletal Muscle Liver Cirrhosis Sham Operation Renal Cortex Abdominal Wall Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • T. Brendler
    • 1
  • R. Heinrich
    • 1
  • S. Dette
    • 1
  • M. Günderoth-Palmowski
    • 1
  • M. Grein
    • 1
  • E. Huber
    • 1
  • W. Grauer
    • 1
  • W. Fleckenstein
    • 1
  • H. Schomerus
    • 1
  1. 1.Medizinische Universitätsklinik Tübingen74 TübingenGermany

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