Control of O2 Supply to the Stimulated Exocrine Pancreas

  • H. J. M. Beijer
  • A. J. G. Holtgrefe
  • M. Woerlee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


The involvement of blood flow in metabolic activity was investigated in the exocrine pancreas in the anesthetized dog using secretin as the specific stimulus. After a bolus injection of secretin (1 U/kg) the exocrine secretion as well as the O2 consumption were increased in the same way. The increased O2 supply was accomplished by changes of blood flow and/or O2 extraction: during the build-up of the response (first 2 min) blood flow was increased before or simultaneous with the increase of secretion. At the same time O2 extraction decreased, which is quite unexpected during stimulation of the metabolic O2 demand. During the 2nd phase (2–16 min) blood flow returned to its initial level very rapidly, while O2 extraction continued to rise. During the 3rd phase (16–30 min) secretion returned to its initial level, as did O2 consumption and O2 extraction.


Blood Flow Metabolic Control Capillary Density Diffusion Capacity Exocrine Pancreas 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • H. J. M. Beijer
    • 1
  • A. J. G. Holtgrefe
    • 1
  • M. Woerlee
    • 1
  1. 1.Exp. Lab. Peripheral Circulation and Dept. of Theoretical BiologyUniversity of UtrechtUtrechtThe Netherlands

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