Perfusate Oxygenation and Renal Function in the Isolated Rat Kidney
Measurements of glomerular and tubular function in the hypoxic kidney were complicated in vivo by the effects of increased levels of circulating vasoconstrictory hormones and a raised sympathetic nervous activity. In consequence, a severe renal vasoconstriction and the resulting reduction in renal blood flow restrained glomerular and tubular functions at very low oxygen tensions (Bursaux et al., 1976; Zillig et al., 1978). Even in vitro, without nervous interference, the perfusion of an isolated kidney preparation with whole blood (Nizet et al., 1967) or Ringer solutions (Ross, 1978) was often hampered by a long lasting vasoconstriction which reduced perfusion flow rate and kept glomerular filtration and tubular Na+ reabsorption far below their physiological levels (Maack, 1980).
KeywordsGlomerular Filtration Rate Oxygen Delivery Exogenous Substrate Urinary Loss Perfusion Flow Rate
Unable to display preview. Download preview PDF.
- Baumann, K., 1981, in: “Renal transport of organic substances”, Springer, Berlin.Google Scholar
- Bergmeyer, H.U. (Ed.), 1974, in: “Methoden der enzymatischen Analyse”, Vol. I and II, Chemie, Weinheim.Google Scholar
- Gronow, G., P. Benk, and H. Franke, 1985, Effects of anaerobic substrates on post-anoxic cellular function in isolated tubular segments of rat kidney cortex, in: “Oxygen transport to tissue”, Vol. VI, Adv. Exp. Med. Biol., Plenum, New York (in print).Google Scholar
- Gronow, G.H.J., and J.J. Cohen, 1984. Substrate support for renal function during hypoxia in the perfused rat kidney. Am. J. Physiol. (in print).Google Scholar
- Ross, B. D., 1978, The isolated perfused rat kidney. Clin. Sc. Molec. Med. 55: 513.Google Scholar