Perfusate Oxygenation and Renal Function in the Isolated Rat Kidney

  • Gemot Gronow
  • Herbert Kossmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


Measurements of glomerular and tubular function in the hypoxic kidney were complicated in vivo by the effects of increased levels of circulating vasoconstrictory hormones and a raised sympathetic nervous activity. In consequence, a severe renal vasoconstriction and the resulting reduction in renal blood flow restrained glomerular and tubular functions at very low oxygen tensions (Bursaux et al., 1976; Zillig et al., 1978). Even in vitro, without nervous interference, the perfusion of an isolated kidney preparation with whole blood (Nizet et al., 1967) or Ringer solutions (Ross, 1978) was often hampered by a long lasting vasoconstriction which reduced perfusion flow rate and kept glomerular filtration and tubular Na+ reabsorption far below their physiological levels (Maack, 1980).


Glomerular Filtration Rate Oxygen Delivery Exogenous Substrate Urinary Loss Perfusion Flow Rate 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Gemot Gronow
    • 1
  • Herbert Kossmann
    • 1
  1. 1.Physiologisches InstitutUniversität KielKiel 1Germany

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