Endotoxin Protection against Oxygen Toxicity and its Reversal by Salicylate

  • J. Klein
  • A. Trouwborst
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


It has long been recognised that prolonged exposure to high inspired oxygen concentrations can produce pulmonary damage. Exposure to 100% O2 at 1 atm. of pressure is lethal to most mammalian species after a period of days to weeks (1). While the potential dangers of hyperoxia on the lung are generally recognised, administration of above ambient O2 tensions remains a necessity in the treatment of severe hypoxemia caused by respiratory failure or acute lung injury.


Acute Lung Injury Oxygen Toxicity Endotoxin Administration Lysine Acetylsalicylate Prostaglandin Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Clark JM and Lambersten CG. Pulmonary oxygen toxicity, a review. Pharmacol Rev 23; 37–113 (1971).PubMedGoogle Scholar
  2. 2.
    Frank L and Roberts RJ. Oxygen toxicity: protection of the lung by the bacterial lipopolysaccharide (endotoxin). Toxicol Appl Pharmacol 50; 371 (1979).PubMedCrossRefGoogle Scholar
  3. 3.
    Frank L and Roberts RJ. Endotoxin protection against oxygen-induced acute and chronic lung injury. J Appl Physiol 47; 577 (1979).PubMedGoogle Scholar
  4. 4.
    Frank L, Summerville J, Massaro D. Protection from oxygen toxicity with endotoxin: role of the endogenous antioxidant enzymes of the lung. J Clin Invest 65; 1104 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    Frank L, Yam J, Roberts RJ. The role of endotoxin in protection of adult rats from oxygen-induced lung toxicity. J Clin Invest 61; 269 (1978).PubMedCrossRefGoogle Scholar
  6. 6.
    Coker SJ, Hughes B, Parratt JR, Rodger IW, Zeitlin IJ. The release of prostanoids during the acute pulmonary response to E.coli endotoxin in anaesthetized cats. Br J Pharmac 78; 561–570 (1983).CrossRefGoogle Scholar
  7. 7.
    Parratt JR and Sturgess RM. E.coli endotoxin shock in the cat; treatment with indomethacin. Br J Pharmac 53; 485–488 (1975).CrossRefGoogle Scholar
  8. 8.
    Wilcoxon F. Some rapid approximate statistical procedures. Stamford, Conn: American Cyanamid Co (1949).Google Scholar
  9. 9.
    Villa S and de Gaetano G. Prostacyclin-like activity in rat vascular tissues. Fast, long-lasting inhibition by treatment with lysine acetylsalicylate. Prostaglandins 14;6,1117 (1977).PubMedCrossRefGoogle Scholar
  10. 10.
    Freeman BA and Crapo JD: Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria. J Biol Chem 256; 21, 10986–10992 (1981).PubMedGoogle Scholar
  11. 11.
    Crapo JD, Freeman BA, Barry BE, Turrens JF, Young SL. Mechanisms of hyperoxic injury to the pulmonary microcirculation. The Physiologist 26; 3, 170–175 (1983).PubMedGoogle Scholar
  12. 12.
    Moncada S, Gryglewski RJ, Buntin J, Vane JR. A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation. Prostaglandins 12; 5, 715–737 (1976).PubMedCrossRefGoogle Scholar
  13. 13.
    Slotman GJ, Machiedo GW, Casey KF, Lyons MJ. Histologic and hemodynamic effects of prostacyclin and prostaglandin El f following oleic acid infusion. Surgery 92; 1, 93–100 (1982).PubMedGoogle Scholar
  14. 14.
    Villa S, de Gaetano G, Semeraro N. Increased vascular prostacyclin activity in rats after endotoxin administration. Experientia 37; 494–495 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • J. Klein
    • 1
  • A. Trouwborst
    • 1
  1. 1.Department of AnaesthesiaErasmus UniversityRotterdamThe Netherlands

Personalised recommendations