Endotoxin Protection against Oxygen Toxicity and its Reversal by Salicylate
It has long been recognised that prolonged exposure to high inspired oxygen concentrations can produce pulmonary damage. Exposure to 100% O2 at 1 atm. of pressure is lethal to most mammalian species after a period of days to weeks (1). While the potential dangers of hyperoxia on the lung are generally recognised, administration of above ambient O2 tensions remains a necessity in the treatment of severe hypoxemia caused by respiratory failure or acute lung injury.
KeywordsAcute Lung Injury Oxygen Toxicity Endotoxin Administration Lysine Acetylsalicylate Prostaglandin Metabolism
Unable to display preview. Download preview PDF.
- 8.Wilcoxon F. Some rapid approximate statistical procedures. Stamford, Conn: American Cyanamid Co (1949).Google Scholar