Hypoxic Pulmonary Vasoconstriction in the Newborn Pig — An Experimental Model
During the process of birth, drastic changes occur in the environment of the foetus as its oxygen supply changes from one delivered by extracorporeal circulation through the umbilical cord to oxygen supply (and carbon dioxide removal) via its own lungs. These changes are accompanied by well-documented alterations in pulmonary haemodynamics (Nelson, 1976). Little is known about the mediating factors which induce these changes and the aim of this study was to gain more insight into some of the factors involved in this physiological process.
KeywordsPulmonary Artery Pressure Pulmonary Vascular Resistance Hypoxic Pulmonary Vasoconstriction Carbon Dioxide Removal Prostaglandin Endoperoxide
Unable to display preview. Download preview PDF.
- Cassin, S., 1980, Role of Prostaglandins and Thromboxanes in the control of the pulmonary circulation in the fetus and newborn, Semin in Perinatol., 4: 101.Google Scholar
- Hamberg, M., and Samuelsson, B., 1974 b, Prostaglandin endoper-oxides. Novel transformations of arachidonic acid in human platelets., Proc Natl Acad Sci USA., 71.Google Scholar
- Nelson, N.M., 1976, Respiration and circulation before birth, in: “Physiology of the newborn infant”, Nelson, N.M. and Smith, C.A., eds., Thomas, Springfield, 4th edition.Google Scholar