Advertisement

Hypoxic Pulmonary Vasoconstriction in the Newborn Pig — An Experimental Model

  • E. I. de Stoppelaar
  • F. G. Leicher
  • G. J. Rees
  • W. Erdmann
  • N. S. Faithfull
  • H. van der Zee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)

Abstract

During the process of birth, drastic changes occur in the environment of the foetus as its oxygen supply changes from one delivered by extracorporeal circulation through the umbilical cord to oxygen supply (and carbon dioxide removal) via its own lungs. These changes are accompanied by well-documented alterations in pulmonary haemodynamics (Nelson, 1976). Little is known about the mediating factors which induce these changes and the aim of this study was to gain more insight into some of the factors involved in this physiological process.

Keywords

Pulmonary Artery Pressure Pulmonary Vascular Resistance Hypoxic Pulmonary Vasoconstriction Carbon Dioxide Removal Prostaglandin Endoperoxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cassin, S., 1980, Role of Prostaglandins and Thromboxanes in the control of the pulmonary circulation in the fetus and newborn, Semin in Perinatol., 4: 101.Google Scholar
  2. v Euler, U.S. and Liljestrand, G., 1946, Observations on the pulmonary arterial blood pressure in the cat, Acta Physiol Scand., 12: 301.CrossRefGoogle Scholar
  3. Fishman, A.P., 1961 a, The clinical significance of the pulmonary collateral circulation, Circulation., 24: 677.PubMedCrossRefGoogle Scholar
  4. Fishman, A.P., 1961 b, Respiratory gases in the regulation of the pulmonary circulation, Physiol Rev., 41: 214.PubMedGoogle Scholar
  5. Friedman, L.S., Fitzpatrick, T.M., Bloom, M., Ramwell, P.W., Rose, J.W. and Kot, P.A., 1979, Cardiovascular and pulmonary effects of Thromboxane B2 in the dog, Circul Res., 44: 748.CrossRefGoogle Scholar
  6. Bamberg, M. and Samuelsson, B., 1974 a, Prostaglandin endoper-oxides. VII. Novel transformations of arachidonic acid in guinea pig lung, Biochem Biophys Res Commun., 61: 942.CrossRefGoogle Scholar
  7. Hamberg, M., and Samuelsson, B., 1974 b, Prostaglandin endoper-oxides. Novel transformations of arachidonic acid in human platelets., Proc Natl Acad Sci USA., 71.Google Scholar
  8. Lloyd, T.C. Jr., 1967, Influence of P02 and pH on resting and active tensions of pulmonary arterial strips, J Appl Physiol., 22: 1101.PubMedGoogle Scholar
  9. Naeye, R.L., 1961, Arterial changes during the perinatal period, Arch Path., 71: 121.PubMedGoogle Scholar
  10. Naeye, R.L. and Letts, H.W., 1962, The effects of prolonged neonatal hypoxemia on the pulmonary vascular bed and heart, Pediatrics, 30: 902.PubMedGoogle Scholar
  11. Nelson, N.M., 1976, Respiration and circulation before birth, in: “Physiology of the newborn infant”, Nelson, N.M. and Smith, C.A., eds., Thomas, Springfield, 4th edition.Google Scholar
  12. Sykes, M.K., Davies, D.M., Chakrabarti, M.K. and Loh, L., 1973, The effects of halothane, trichloroethylene and ether on the hypoxic pressor response and pulmonary vascular resistance in the isolated perfused cat lung, Brit J Anaesth., 45: 655PubMedCrossRefGoogle Scholar
  13. Tuvemo, T., Strandberg, K., Hamberg, M. and Samuelsson, B., 1976, Formation and action of prostaglandin endoperoxides in the isolated umbilical artery, Acta Physiol Scand., 96: 145.PubMedCrossRefGoogle Scholar
  14. Wolfe, L.S., Rostworowski, K. and Marion, J., 1976, Endogenous formation of the prostaglandin endoperoxide metabolite,CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • E. I. de Stoppelaar
    • 1
  • F. G. Leicher
    • 2
  • G. J. Rees
    • 1
  • W. Erdmann
    • 1
  • N. S. Faithfull
    • 1
  • H. van der Zee
    • 3
  1. 1.Departments of AnaesthesiaErasmus UniversityRotterdamThe Netherlands
  2. 2.Departments of Cardiothoracic SurgeryErasmus UniversityRotterdamThe Netherlands
  3. 3.Department of AnaesthesiaAlbany Medical CollegeNew YorkUSA

Personalised recommendations