Carboxyhemoglobin: Determination and Significance in Oxygen Transport
Apart from being the direct cause of quite a few cases of near-fatal poisoning, carbon monoxide is a very common noxious agent functioning as an additional factor in human disease. The extent of the possible role of carbon monoxide in human pathology is demonstrated by the following data from the Diakonessenhuis Groningen, a 400-bed private hospital1. During a five-month period the carboxyhemoglobin fraction (FHbCO) was measured in the blood of all pre-operative patients. In 64.4% of the 1358 cases FHbCO was < 1.5%, in 26.8% it was between 1.5 and 5.0%, in 8.5% between 5.0 and 10.0% and in 0.4% it was > 10%. The highest value measured in this series was 15.5%. Thus it appears that in a considerable number of patients HbCO fractions are present that are of possible pathophysiological significance. This shows the practical importance of the pathophysiology of carboxyhemoglobin and the need for easy and reliable methods for the determination of FHbCO in blood.
KeywordsAbsorbance Ratio Oxygen Affinity Titrimetric Method Isobestic Point Oxygen Dissociation Curve
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