Adaptation of Muscle Capillarity
The single most important physiological factor affecting the capillarity of skeletal and cardiac muscle is normal growth. In both skeletal and cardiac muscle, increases in body size and weight are associated with increases in the cross sectional area of existing fibers and decreases in capillary density which result in longer diffusion distances (Aquin et al., 1980; Kayar et al., 1982). These normal decreases in capillary density occur despite increases in the total number of capillaries which are measured as increases in the capillary density to fiber density ratio (C/F). However, it is not clear what factors are involved in the development of new capillaries in muscle growth.
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