Oxygen Exchanges between Blood and Resting Skeletal Muscle: A Shunt-Sink Hypothesis
Prevously we have reported the use of oxygen-18 isotope and double indicator dilution methodology to measure the exchanges of eoxygen between blood and brain tissues (Grieb et al., 1983). In the present experiments we used the same technique for the study of a canine hind limb preparation. To our knowledge, oxygen isotopes have not been used to study the features of oxygen delivery to muscles, with the exception of preliminary studies of Forster, el al. (1976) and Rose and Goreski (1982). More is known about the distribution of inert diffusible tracers in muscle preparations; (eg. Aukland and Leraand, 1960; Paradise et al., 1971; Piiper and Meyer, in press; Sparks and Mohrman, 1977; Tonnesen and Sjersen, 1967), and such data are sometimes extrapolated to oxygen.
KeywordsSlow Component Venous Outflow Dilution Curve Tritiated Water Double Circulation
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