Myocardial Ischemic Injury and β-Adrenergic Receptors in Perfused Working Rabbit Hearts

  • H. M. Rhee
  • L. Tyler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


Adrenergic nerve system modulates a host of diverse physiological functions in health and diseases.1–4 Recent advances in the study of adrenergic receptors have contributed greatly to an understanding of both alpha- and beta-adrenergic receptors and their subtypes. Availability of radioactive agonists and antagonists in high specific activity allowed to access directly the density and property of the receptors. However, their role in acute effect of myocardial ischemia on cardiac metabolism and function is poorly understood.


Ischemic Heart Adrenergic Receptor Contractile Force Left Ventricular Pressure Rabbit Heart 
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  1. 1.
    B. B. Hoffman and R. J. Lefkowitz, Ann. Rev. Physiol. 44:475–84 (1982).CrossRefGoogle Scholar
  2. 2.
    J. B. Martins, R. E. Rekerber, M. L. Marcus, D. L. Laughlin, and D. M. Levy, Cardiovasc. Res. 14:116–124 (1980).PubMedCrossRefGoogle Scholar
  3. 3.
    P.R.J. Burch, Cardiovas. Res. 14:307–338 (1980).CrossRefGoogle Scholar
  4. 4.
    B. B. Hoffman and R. J. Lefkowitz, New Eng. J. Med. 302:1390–1396 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    H. M. Rhee, and J. Cooper, Functional alteration of membrane integrity during global ischemic injury in perfused rabbit heart. in: “Oxygen Transport to Tissue, vol. v.” D. W. Lubbers et al., ed., Plenum Publising Corp., New York, 1984.Google Scholar
  6. 6.
    R. B. Jennings, H. K. Hawkins, J. E. Lowe, M. L. Hill, M. S. Klotman, and K. A. Reimer, Am. J. Pathol. 92:187–214 (1978).PubMedGoogle Scholar
  7. 7.
    J. R. Neely, M. J. Rovetto, J. T. Whitmer, and H. E. Morgan, Amer. J. Physiol. 225:651–658 (1973).PubMedGoogle Scholar
  8. 8.
    W. Huang, H. M. Rhee, R. H. Chiù, and A. Askari, J. Pharmacol. Exp. Ther. 211:571–582 (1979).PubMedGoogle Scholar
  9. 9.
    R. W. Alexander, L. T. Williams, and R. J. Lefkowitz, Proc. Natl. Acad. Sci. USA 72:1564–1568 (1975).PubMedCrossRefGoogle Scholar
  10. 10.
    G. Scatchard, Ann. N.Y. Acad. Sci. 51:660–672 (1949).CrossRefGoogle Scholar
  11. 11.
    R. B. Jennings and C. E. Ganote, Cir. Res. 34 and 35 (Suppl. III): 156–172 (1974).Google Scholar
  12. 12.
    G. A. Beller, J. Conroy, and T. W. Smith, 57:341–350 (1976).Google Scholar
  13. 13.
    B. E. Hopkins and R. R. Taylor, J. Mol. Cell. Cardiol. 36:902–907 (1973).Google Scholar
  14. 14.
    R. B. Jennings, C. E. Ganóte, and K. A. Reimer, Amer. J. Pathol. 81:179–198 (1975).Google Scholar
  15. 15.
    R. J. Lefkowitz, C. Mukherjee, M. Coverstone, and M. G. Caron, Biochem. Biophys. Res. Comm. 60 (#2):703–709 (1974).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • H. M. Rhee
    • 1
  • L. Tyler
    • 1
  1. 1.Department of PharmacologyOral Roberts University School of MedicineTulsaUSA

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