Oxygen Diffusion in a Heart Muscle Fibre

  • D. L. S. McElwain
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)


The role of myoglobin in the function of muscle fibres has been the subject of many investigations. For many years it was thought that its main function in muscle is to act as a resevoir for oxygen with which it combines reversibly. In the 1960’s, however, there were a number of papers which suggested that myoglobin is involved in intracellular oxygen transport.


Oxygen Diffusion Oxygen Transport Free Oxygen Heart Muscle Fibre Fibre Radius 
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  1. Cole, R.P., Wittenberg, B.A., and Caldwell, P.R.B., 1978, Myoglobin function in the isolated fluorocarbon-perfused dog heart, Am.J.Physiol., 234:H567.PubMedGoogle Scholar
  2. Folkow, B., and Neil, E., 1971, “Circulation”, Oxford University Press, New York.Google Scholar
  3. Jones, D.P., and Kennedy, F.G., 1982, Intracellular O2 gradients in cardiac myocytes. Lack of a role for myoglobin in facilitation of intracellular O2 diffusion, Biochem.Biophys. Res.Comm., 105:419.PubMedCrossRefGoogle Scholar
  4. Kreuzer, F., and Hoofd, L.J.C., 1970, Facilitated diffusion of oxygen in the presence of hemoglobin, Resp.Physiol., 10:542.Google Scholar
  5. Mitchell, P.J., and Murray, J.D., 1973, Facilitated diffusion: The problem of boundary conditions, Biophysik, 9:177.PubMedCrossRefGoogle Scholar
  6. Murray, J.D., 1971, On the molecular mechanism of facilitated oxygen diffusion by haemoglobin and myoglobin, Proc.Roy.Soc. Lond.B., 178:95.CrossRefGoogle Scholar
  7. Murray, J.D., 1974, On the role of myoglobin in muscle respiration, J.Theor.Biol., 47:115.PubMedCrossRefGoogle Scholar
  8. Murray, J.D., 1976, On the functional role of myoglobin in skeletal muscle, Tiré à part, Myoglobin, Colloquium on Myoglobin, Brussels, Université Libre de Bruxelles.Google Scholar
  9. Rubinow, S.I., and Dembo, M., 1977, The facilitated transport of oxygen by hemoglobin and myoglobin, Biophys.J., 18:29.PubMedCrossRefGoogle Scholar
  10. Stokes, A.N., 1976, Capillary auto-regulation and the role of myoglobin, Microvasc.Res., 11:261.PubMedCrossRefGoogle Scholar
  11. Tamura, M., Oshino, N., Chance, B. and Silver, I.A., 1978, Optical measurements of intracellular oxygen concentration of rat heart in vitro, Arch.Biochem.Biophys., 191:8.PubMedCrossRefGoogle Scholar
  12. Taylor, B.A., and Murray, J.D., 1977, Effect of the rate of oxygen consumption on muscle respiration, J.Math.Biol., 4:1.PubMedCrossRefGoogle Scholar
  13. Wearn, J.T., 1940, Morphological and functional alterations of the coronary circulation, Harvey Lect.Series, 35:243.Google Scholar
  14. Wittenberg, B.A., Wittenberg, J.B., and Caldwell, P.R.B., 1975, Role of myoglobin in the oxygen supply to red skeletal muscle, J.Biol.Chem., 250:9038.PubMedGoogle Scholar
  15. Wittenberg, J.B., 1970, Myoglobin-facilitated oxygen diffusion: Role of myoglobin in oxygen entry in muscle, Physiol.Rev., 50:559.PubMedGoogle Scholar
  16. Wyman, J., 1966, Facilitated diffusion and the possible role of myoglobin as a transport mechanism, J.Biol.Chem., 241:115.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • D. L. S. McElwain
    • 1
  1. 1.Department of Mathematics, Statistics and Computer ScienceUniversity of NewcastleAustralia

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