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The Effect of Heterogeneity of Capillary Spacing and O2 Consumption — Blood Flow Mismatching on Myocardial Oxygenation

  • Karel Rakusan
  • Zdenek Turek
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)

Abstract

Previously we demonstrated the importance of the heterogeneity of the capillary spacing for the oxygen supply to the myocardial tissue (Turek and Rakusan, 1981). The computed percentage of anoxic myocardial tissue turned out to be a better index of tissue oxygenation than the mean myocardial PO2. This was especially apparent in situations associated with myocardial hypoxia. The percentage of anoxic myocardial tissue depends not only on the average values of the traditional oxygen determinants included in the Krogh-Erlang equation but also on their variability. In our previous report we analyzed the dependence of myocardial oxygenation on the degree of heterogeneity of capillary spacing for a single value of the mean tissue radius (R) in two situations with respect to blood flow distribution. In the first situation (A) the volume blood flow was perfectly matched to the size of tissue cylinder supplied by a given capillary resulting in uniform end-capillary PO2. In the second situation (B) identical blood flow was assumed for all capillaries resulting in varying end-capillary PO2. If uniform oxygen consumption is assumed, then in this situation the O2 consumption and blood flow must be seriously mismatched. In most cases the real situations obviously lie between these two extreme conditions.

Keywords

Oxygen Supply Myocardial Oxygen Consumption Capillary Blood Flow Cylinder Radius Volume Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Rakusan, K., 1971, Quantitative morphology of capillaries of the heart, in: Functional Morphology of the Heart, E. Bajusz and G. Jasmin, eds., Karger, Basel, pp 272–286.Google Scholar
  2. Rakusan, K., Hoofd, L.J.C., and Turek, Z., 1985, The effect of cell size and capillary spacing on myocardial oxygen supply, in: Oxygen Transport to Tissue-VI, D.F. Bruley et al., eds., Plenum Press, New York and London, in press.Google Scholar
  3. Turek, Z., and Rakusan, K., 1981, Lognormal distribution of inter-capillary distance in normal and hypertrophic rat heart as estimated by the method of concentric circles: Its effect on tissue oxygenation. Pflügers Arch., 391:17–21.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Karel Rakusan
    • 1
    • 2
  • Zdenek Turek
    • 1
    • 2
  1. 1.Department of Physiology, School of MedicineUniversity of OttawaOttawaCanada
  2. 2.Department of Physiology, Faculty of MedicineUniversity of NijmegenNijmegenThe Netherlands

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