Variability of Intercapillary Distance Estimated on Histological Sections of Rat Heart
The majority of models of O2 supply to myocardial tissue are based on the classical model of Krogh (1919). This model requires the radius of the tissue cylinder as one of the crucial input data. Usually, only its mean value has been considered, as derived on histological sections from the number of capillaries per mm2. However, for a realistic description, the full distribution of the radii of the tissue cylinders has to be taken into account. Recently this distribution was shown to be approximately log-normal (Renkin et al., 1981; Turek and Rakusan, 1981), and thus to be fully defined by median radius and logarithmic standard deviation (log SD), the latter serving as an index of the variability.
KeywordsDomain Method Heterogeneity Index Spontaneous Hypertension Tissue Cylinder Capillary Spacing
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