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Myocardial Oxygen Consumption and Autoregulation of the Coronary Vascular Bed

  • Isabelle Vergroesen
  • Mark I. M. Noble
  • Dirk L. Ypey
  • Jos A. E. Spaan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 191)

Abstract

The local control of vascular resistance is characterized by a relatively constant coronary flow during changes in perfusion pressure (autoregulation) and the ability of coronary flow to match increased metabolic requirements (metabolic regulation). Generally it is assumed that perfusion pressure does not affect heart metabolism (Feigl, 1983) although there is some evidence of the contrary (Gregg, 1963; Arnold et al., 1970). Under physiological conditions with aortic pressure as perfusion pressure of the coronary vascular bed, changes in mean aortic pressure (exercise, hypertension) cause significant changes in coronary blood flow via both myocardial oxygen consumption and perfusion pressure (Bugni et al., 1980). Relating coronary flow exclusively to oxygen consumption (Rubio & Berne, 1975; Eckenhoff et al., 1947) ignores the possible direct effect of perfusion pressure on flow. The oxygen hypothesis as formulated by Laird (Laird & Spaan, 1981; Drake-Holland et al., 1984) predicts a linear relation between coronary flow and both perfusion pressure and oxygen consumption. The aim of this study was to test this hypothesis applying multiple linear regression analysis to experimental data obtained from the in situ cannulated coronary bed of anaesthetised open chest dog and goat.

Keywords

Oxygen Consumption Perfusion Pressure Coronary Flow Coronary Blood Flow Aortic Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Arnold, G., Morgenstern, O., Lochner, W., 1970. The autoregulation of the heart work by the coronary perfusion pressure. Pflügers Arch., 321:34.PubMedCrossRefGoogle Scholar
  2. Bugni, W.J., Kralios, A.C., Tsagaris, T.J., Kuida, H., 1980. Effect of arterial pressure on left ventricular O2 consumption, coronary blood flow and reserve capacity following coronary occlusion. Am. Heart J., 100:657.PubMedCrossRefGoogle Scholar
  3. Drake-Holland, A.J., Laird, J.D., Noble, M.I.M., Spaan, J.A.E., Vergroesen, I., 1984. Oxygen and coronary vascular resistance during autoregulation and metabolic vasodilation in the dog. J. Physiol., 348:285.PubMedGoogle Scholar
  4. Eckenhoff, J.E., Hafkenschiel, J.H., Landmesser, C.M., Harmel, M., 1947. Cardiac oxygen metabolism and control of the coronary circulation. Am. J. Physiol., 149:634.PubMedGoogle Scholar
  5. Farn, W.M., McGregor, M., 1969. Pressure-flow relationships in the coronary circulation. Circ. Res., 25:293.CrossRefGoogle Scholar
  6. Feigl, E.O., 1983. Coronary Physiology. Physiol. Rev., 63:1.PubMedGoogle Scholar
  7. Gregg, D.E., 1963. Effect of coronary perfusion pressure or coronary flow on oxygen usage of the myocardium. Circ. Res., 13:497.PubMedCrossRefGoogle Scholar
  8. Jan, K.M., Chien, S., 1977. Effect of hematocrit variations on coronary hemodynamics and oxygen utilization. Am. J. Physiol., 233:11106Google Scholar
  9. Laird, J.D., Spaan, J.A.E., 1981. A simple computer model of coronary flow regulation based on interstitial oxygen tension. J. Physiol., 324:1P.Google Scholar
  10. Rubio, R, Berne, R.M., 1975. Regulation of coronary blood flow. Prog. Cardiovasc. Pis., 18:105.CrossRefGoogle Scholar
  11. Scharf, S.M., Bromberger-Barnea, B., Permutt, S., 1971. Distribution of coronary venous flow. J. Appl. Physiol., 30:657–662.PubMedGoogle Scholar
  12. Spaan, J.A.E., Breuls, N.P.W., Laird, J.D., 1981. Diastolic-systolic coronary flow differences are caused by intramyocardial pump action in the anesthetized dog. Circ. Res., 49:584.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Isabelle Vergroesen
    • 1
  • Mark I. M. Noble
    • 2
  • Dirk L. Ypey
    • 1
  • Jos A. E. Spaan
    • 1
  1. 1.Department of Physiology and Physiological PhysicsState UniversityLeidenThe Netherlands
  2. 2.King Edward VII HospitalMidhurst, West SussexUK

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