The Effect of Peptides on Cerebrovascular Resistance in Cats
It was the aim of the present study to investigate the effect of several naturally occurring peptides and synthetic analogues on cerebral resistance vessels. These peptides appear to be generated and released in the brain from vascular nerve endings or parenchymal cells. Neurotensin, a tridecapeptide, was first isolated from extracts of hypothalamus by Carraway and Leeman (1973) and later also detected in other brain regions such as cortex, thalamus, and pituitary (Bisette et al., 1978; Brown and Miller, 1982). In addition, neurotensin immunoreactive fibres have been detected in cerebral vessels by Chan-Palay (1977).
KeywordsOpiate Receptor Intestinal Smooth Muscle Bradykinin Receptor Pial Artery Vasogenic Brain Edema
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