Changes in Regional Cerebrovascular Resistance During Partial Cerebral Ischemia in Rats
Secondary changes in regional cerebral blood flow (rCBF) have been observed to occur within hours to days in acute focal cerebral ischemia. Following experimental occlusion of the middle cerebral artery (MCA) the secondary decline in rCBF during the first 4 hours of ischemia appeared to correlate with progressive brain swelling (Hossmann and Schuier, 1980). In subsequent studies the delayed rise in intracortical vascular resistance as the cause of the decrease in rCBF was noted (Shima et al, 1983). It is assumed that the continuing failure of cerebral hemodynamics associated with the delayed rise in regional cerebral vascular resistance (rCVR) can aggravate the ischemia and in this way can contribute to the extension of cerebral infarction.
KeywordsCerebral Ischemia Middle Cerebral Artery Occlusion Superior Colliculus Regional Cerebral Blood Flow Local Blood Flow
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