Effect of Increasing Heart Rate by Atrial Pacing on Myocardial Tissue Oxygen Tension

  • Harvey R. Weiss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 37 A)


Measurement of tissue oxygen tension of heart muscle by polarography has been extensively performed by many investigators. It has been used to measure normal regional differences in the ventricular walls 6,7,15,17 the effects of various drugs 15,17, gases 8, and physiologic interventions 17. These studies have shown a higher subepicardial tissue oxygen tension (Epi Po2) then subendocardial tissue oxygen tension (Endo Po2) in the left ventricular free wall 6,7. Tissue oxygen tension is controlled by the balance between the oxygen supply and the tissue oxygen demand. The interaction of these two factors in the control of Epi Po2 and Endo Po2 with changes in heart rate are unknown and the rationale for the present study.


Angina Pectoris Oxygen Supply Coronary Blood Flow Left Ventricular Wall High Heart Rate 
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Copyright information

© Springer Science+Business Media New York 1973

Authors and Affiliations

  • Harvey R. Weiss
    • 1
  1. 1.Dept. of PhysiologyCollege of Medicine and Dentistry of N.J. - Rutgers Medical SchoolPiscatawayUSA

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