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New Aspects on the Mechanism of Autoregulation of Blood Flow

  • Christoph Weiss
  • Volker Thiemann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 37 A)

Abstract

The term autoregulation as used here denotes the ability of an isolated organ to keep the blood flow relatively constant in spite of changes of perfusion pressure. In previous communications pertaining to a system theory analysis of autoregulation (1,2,3,4,5, 6) we reported observations on periodic spontaneous fluctuations of the perfusion flow (v)of isolated rat kidneys, isolated rat hearts, isolated hind limbs and isolated mesentery showing periodicities in the range of 25 sec. (6). These fluctuations which were only observed when the arterial pressure was maintained at values higher than 80–100 mm Hg (i.e. in the range of autoregulation) did not appear as proper sinusoidal oscillations with defined shapes and constant periodicity. Instead, irregular increases and decreases of the flow (v) of varying periodicity were observed (fig.1). A more detailed study of these irregular periodic changes, seemed to promise information on the nature of the underlying pro-cess. Especially so since similar periodicities were previously reported from other circulatory areas and from smooth muscle preparations (3, 7–13). For this purpose we have applied the method of time series analysis consisting in the determination of autocorrelation and power spectral density functions.

Keywords

Perfusion Pressure Power Density Spectrum Pressure Step Power Spectral Density Function Circulatory Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Basar, E., Tischer, H., Weiss Ch.: Pflügers Arch. ges. Physiol. 299, 191–213 (1968).Google Scholar
  2. 2.
    Basar, E., Rhedas, G., Schwarzkopf, H.J., Weiss, Ch.: Pflügers Arch. 304, 189–202 (1968).PubMedCrossRefGoogle Scholar
  3. 3.
    Basar, E., Weiss, Ch.: Pflügers Arch. 304 121–135 (1968).PubMedCrossRefGoogle Scholar
  4. 4.
    Basar, E., Weiss, Ch.: Kybernetik 5, 241–247 (1969).CrossRefGoogle Scholar
  5. 5.
    Bendat, J.S., Piersol, A.G.: New York: John Wiley & Sons, Inc. 1967.Google Scholar
  6. 6.
    Basar. E., Weiss, Ch.: Pflügers Arch. 319, 205–214 (1970)CrossRefGoogle Scholar
  7. 7.
    Gebert, G., Konold, P., Seboldt, H.: Pflügers Arch. 299, 285–294 (1968).CrossRefGoogle Scholar
  8. 8.
    Golenhofen, K. in Smooth muscle, chapt.: Slow Rhythms in smooth muscle. ed. Bülbring, E., A.F. Brading, A.W. Jones, T.Tomita. Edward Arnold Ltd.London 1970.Google Scholar
  9. 9.
    Johannson, B., Ljung, B.: Acta physiol. scand. 70, 299–311 (1967).CrossRefGoogle Scholar
  10. 10.
    Johnson, P.C., Wayland, H.: Am. J. Physiol. 212, 1405 (1967).PubMedGoogle Scholar
  11. 11.
    Koepchen, H.P., Polster, J., Langhorst, P.: Pflügers Arch. 278, 24 (1963).CrossRefGoogle Scholar
  12. 12.
    Seller, H., Langhorst, P., Polster, J. Koepchen, H.P.: Pflügers Arch. 296, 110–132 (1967).CrossRefGoogle Scholar
  13. 13.
    Stolp, W., Thiemann, V., Weiss, Ch.: 11. Internat. Sympos. Biokybernetik, Leipzig 1969.Google Scholar
  14. 14.
    Folkow, B., Circulation Res., Suppl. 1, XV, 279–285 (1964).Google Scholar

Copyright information

© Springer Science+Business Media New York 1973

Authors and Affiliations

  • Christoph Weiss
    • 1
  • Volker Thiemann
    • 1
  1. 1.Physiologisches Institut der UniversitätKielGermany

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