Tissue PO2 Levels in the Liver of Warm and Cold Rats Artificially Respired with Different Mixtures of O2 and CO2

  • James A. MillerJr.
  • Manfred Kessler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 37 A)


Studies by Giaja, Andjus, Smith and others demonstrated clearly that when animals are cooled in sealed vessels while being exposed to decreasing oxygen and increasing CO2 levels, they can be reanimated in 90–100% of the cases from body temperatures near 0°C. Both hypoxia and hypercapnia were found to contribute significantly to the success of the technique (3). Lewis, using artificial respiration with 95% O2+5% CO2 or 90% O2+10% CO2 concluded that it was impossible to resuscitate mammals at 10 °C or less unless CO2 was used (2).


Oxygen Transport Artificial Respiration Precipitous Fall Liver Hypoxia High Arterial Blood Pressure 
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Copyright information

© Springer Science+Business Media New York 1973

Authors and Affiliations

  • James A. MillerJr.
    • 1
    • 2
  • Manfred Kessler
    • 1
    • 2
  1. 1.School of MedicineTulane UniversityDortmundWest Germany
  2. 2.Max-PlanckInstitut für SystemphysiologieTulane UniversityDortmundWest Germany

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