On the Accuracy of an Improved Method for the Measurement of O2-Dissociation-Curves According to Niesel & Thews,1961

  • Wolfgang Barnikol
  • Waltraud Wahler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 37 A)


During the first part of its journey to tissue oxygen is carried by blood. The greatest part thereby is bound chemically to hemoglobin. The molecular mechanism of this binding gives the so-called O2-dissociation-curve its typical, sigmoidal form. The O2-dissociation-curve is the function between O2-saturation and O2 -parfial-pressure. This curve is of great importance for the O2-supply of ‘he tissues. It is important for practice as well as for formulating a theory in this field. Within the last few years it has been discovered, that the O2-dissociation-curve is influenced by organic phospha-tes, e.g. 2,3-DPG (CHANUTIN, CURNISH, 1967; BENESCH, BENESCH, 1967). Because of this new discovery a correlation to metabolism and also new therapeutic possibilities have been found. The influence of a low molecular substance on the O2-dissociation-curve could be deduced from a theo-retical analysis of the O2-hemoglobin-equilibrium, too (BARNIKOL, THEWS, 1969).


Blood Smear Oxygen Transport Organic Phosphate Hypertone Solution Oxyhemoglobin Dissociation Curve 
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Copyright information

© Springer Science+Business Media New York 1973

Authors and Affiliations

  • Wolfgang Barnikol
    • 1
  • Waltraud Wahler
    • 1
  1. 1.Physiologisches Institut der UniversitätMainzDeutschland

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