Selective Vulnerability of the Central Nervous System to Hyperbaric Oxygen
The adverse effects of hyperoxia on the central nervous system (CNS) have been well known since the 19th century writing of Paul Bert. Acute CNS oxygen toxicity is manisfested by grand mal convulsions and may result in death following status epilepticus. Bean and Seigfried2 reported a delayed or chronic type of oxygen poisoning in rats subjected to repeated brief intermittent exposures to hyperbaric oxygen (HO), which resulted in permanent limb paralysis. The paralyses observed in this type of oxygen toxicity usually affect the forelimbs bilaterally with the animals assuming a kangaroolike posture. Rigidity of the paralyzed limbs is common. Animals capable of locomotion are ataxic. A few rats become quadriplegic.
KeywordsNeuronal Cell Body Selective Vulnerability Ventral Cochlear Nucleus Intermittent Exposure Minute Exposure
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