Response of Feline Brain Tissue to Oscillating Arterial pO2
An experimental system has been developed to investigate the transient response of tissue and cellular pO2 to dynamic changes in perfusion. The in-vivo tissue transients resulting from short episodes of respirator-induced hypoxia were followed in the cerebral cortex of cats while simultaneously measuring tissue pO2, total arterial pO2 and flow rate, venous pO2, and cell action-potential. The system was capable of producing, recording, and correlating oscillations induced by either respirator variations or a computer controlled exchange of venous and arterial blood.
KeywordsExchange System Oxygen Transport Step Change Blood Flow Rate Polarographic Oxygen Electrode
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