Energy-Rich Metabolites and EEG in Hypoxia and in Hypercapnia

  • Ursula Schindler
  • E. Gärtner
  • E. Betz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 37 A)


In the present communication we report the effect of controlled hypoxia, of severe hypercapnia and its recovery upon the metabolic state and the electrical activity of the cerebral cortex in cats. We investigated also the influence of high carbon dioxide tensions in brain metabolites and EEG, maintaining a sufficient oxygen supply to the brain. In the hypoxia experiments the pCO2 was low. The oxygen tension was decreased to such a degree that the EEG disappeared.Isoelectric EEG was also obtained by high CO2 concentrations (2,6,8).


Recovery Group Pyruvate Ratio Hypoxia Experiment Apparent Equilibrium Constant Control Hypoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. (1).
    D.E.Atkinson: Biochemistry 7, 4030–4034 (1967).CrossRefGoogle Scholar
  2. (2).
    E.Betz, U.Knebel, L.Neumann and H.Ngyen-Duong: Pflügers Arch.ges.Physiol 307, R 117–118 (1969).Google Scholar
  3. (3).
    O.H.Lowry, J.V.Passonneau, F.X.Hasselberger and D.W.Schulz: J.Biol.Chem. 239, 18–30 (1964).PubMedGoogle Scholar
  4. (4).
    O.H.Lowry and J.V.Passonneau: J.Biol.Chem. 241, 2268–2279 (1966).PubMedGoogle Scholar
  5. (5).
    J.Scheuer and M.N.Berry: Am.J.Physiol. 213, 1143–1148 (1967).PubMedGoogle Scholar
  6. (6).
    U.Schindler, E.Betz, H.Pfeiffer and M.Strohm: Europ.Neurol. 6, 83–87 (1971/1972).Google Scholar
  7. (7).
    F.W.Schmahl, E.Betz, H.Talke and H.J.Hohorst: Biochem.Z. 342, 518–531 (1965).PubMedGoogle Scholar
  8. (8).
    F.W.Schmahl, E.Betz, E.Dettinger and H.J.Hohorst: Pflügers Arch.ges.Physiol. 292, 46–59 (1966).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1973

Authors and Affiliations

  • Ursula Schindler
    • 1
  • E. Gärtner
    • 1
  • E. Betz
    • 1
  1. 1.Institute of Physiology IUniv.TübingenTübingenW.- Germany

Personalised recommendations