Local PO2 in Relation to Intracellular pH, Cell Membrane Potential and Potassium Leakage in Hypoxia and Shock
In many disease conditions it is ultimately hypoxia at cellular level which leads to reversible or irreversible damage. While searching for the factors which may be of primary importance in inducing this damage, we have examined a number of changes that occur during tissue hypoxia. We have used as our models (a) intact animals during respiratory hypoxia and hemorrhagic shock and, (b) tissue cultures in graded hypoxia. Hemorrhagic shock produces profound hypoxia in many tissues complicated by changes in blood flow, by leakage of fluid into the tissues and by build up of CO2. The two tissues which we have studied in some detail are (a) the population of fibroblasts, endothelial cells and macrophages at the edge of healing wounds, and (b) the neurones and glial cells of the cerebral cortex of the rat.
KeywordsHemorrhagic Shock Extracellular Potassium Hypoxic Episode Spontaneous Electrical Activity Local Hypoxia
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