Evidence for a Relationship Between 2,3-Diphosphoglycerate-Depleted Red Blood Cells, Slow Oxygen Release and Myocardial Ischemia

  • J. W. HolsingerJr.
  • J. M. Salhany
  • R. S. Eliot
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 37 A)


Following the reports of Chanutin and Curnish (1) and Benesch and Benesch (2) in 1967, numerous reports have emerged extending our knowledge of the molecular physiologic and clinical aspects of 2,3-diphosphoglycerate (DPG). Some of these molecular findings may now be tested physiologically using an animal model. The first part of this paper will consider the molecular basis for oxygen release from the red cell while the second will deal with a physiologic model and the question of whether a decrease in the rate of release of oxygen from the red cell can induce myocardial ischemia in the dog.


Balloon Occluder Circumflex Artery Partial Occlusion Physiologic Model Oxygen Affinity 
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Copyright information

© Springer Science+Business Media New York 1973

Authors and Affiliations

  • J. W. HolsingerJr.
    • 1
  • J. M. Salhany
    • 1
  • R. S. Eliot
    • 1
  1. 1.Division of Cardiology, University of Nebraska Medical Center and Department of BiophysicsUniv. of ChicagoUSA

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