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Effects of Reduced 2,3 Diphosphoglycerate on Oxygen Release from Blood of Alloxan Diabetic Rats: Myocardial Cellular Hypoxia

  • T. B. Allison
  • S. P. Bruttig
  • J. C. Shipp
  • R. S. Eliot
  • M. F. CrassIII
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 37 A)

Abstract

The extent of tissue oxygenation in patients with diabetes mellitus has been the subject of several recent reports in the literature (Alberti, et al., 1972; Ditzel, 1972; Bellingham, et al., 1970). The criterion of tissue oxygenation used in these studies was the P50, the oxygen tension at 50% hemoglobin saturation. Interpretation of these results is difficult in that both increased and decreased P50’s were reported. The conditions varied from acute ketoacidosis to non-acidotic, ambulatory patients receiving insulin. An increased P50 was associated with the acute ketoacidotic stage of diabetes while a decreased P50 was associated with insulin treatment.

Keywords

Tissue Oxygenation Diabetic Ketoacidosis Oxygen Release High Energy Phosphate Venous Oxygen Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1973

Authors and Affiliations

  • T. B. Allison
    • 1
  • S. P. Bruttig
    • 1
  • J. C. Shipp
    • 1
  • R. S. Eliot
    • 1
  • M. F. CrassIII
    • 1
  1. 1.Departments of Biochemistry and MedicineUniv. of Nebraska College of MedicineOmahaUSA

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