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P50 Determinations: Techniques and Clinical Importance

  • K. D. Fallon
  • A. L. Malenfant
  • R. D. Weisel
  • H. B. Hechtman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 37 A)

Abstract

The oxyhemoglobin dissociation curve demonstrates the relationship between the partial pressure of oxygen and the percent hemoglobin carrying oxygen. The decrease in this percentage as blood passes from the arterial to venous side of tissue is indicative of the amount of oxygen delivered to that tissue. The four controlling factors governing oxygen delivery to tissue are: oxyhemoglobin concentration, blood flow, tissue PO2 and hemoglobin affinity for oxygen.1 If the affinity of hemoglobin increases, then compensation must occur or there will be a corresponding decrease in oxygen delivery to the tissue. The forms of compensation are increased blood flow (cardiac output), increased oxyhemoglobin concentration or decreased tissue PO2.1 P50 is the PO2 at which hemoglobin is 50% saturated with oxygen. It’s value defines relative changes in oxygen-hemoglobin affinity. To test the hypothesis that decreases in P50 are potentially harmful to an acutely ill individual, we developed procedures for rapidly and easily determining P50.

Keywords

Major Abdominal Surgery Mixed Venous Oxygen Saturation Venous Side Blood Pass Oxyhemoglobin Dissociation Curve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Bibliography

  1. 1.
    Finch, C. A. & C. Lenfant, Oxygen Transport in Man, N. E. J. Med., 286; 407–415, 1972.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1973

Authors and Affiliations

  • K. D. Fallon
    • 1
    • 2
  • A. L. Malenfant
    • 1
    • 2
  • R. D. Weisel
    • 1
    • 2
  • H. B. Hechtman
    • 1
    • 2
  1. 1.Instrumentation LaboratoryLexingtonUSA
  2. 2.Boston University Medical CenterBostonUSA

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