Evidence for Two Secretory Mechanisms for Organic Acid Transport in Man

  • Herbert S. Diamond
  • Allen D. Meisel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)


Pyrazinamide administration markedly impairs the uricosuric response to probenecid in man and in the chimpanzee (1,2). This effect of pyrazinamide on probenecid uricosuria has been attributed to inhibition of urate secretion by pyrazinamide and used as evidence for post secretory reabsorption of urate (1). However, other forms of drug interaction between probenecid and pyrazinamide have not been excluded. Recent evidence from studies in the chimpanzee and man suggest that urate and hippurate are secreted by different transport mechanisms (2,3). The present study was designed to further investigate the mechanism of pyrazinamide inhibition of the uricosuric response to probenecid in man and to compare the Interactions between pyrazinamide and probenecid with those between PAH and probenecid.


Tubular Secretion Luminal Membrane Secretory Mechanism Urate Transport Urate Excretion 
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    Diamond, H.S. and J. S. Paolino. Evidence for a post secretory reabsorptive site for uric acid in man. J. Clin. Invest. 52:1491–1499, 1973.PubMedCrossRefGoogle Scholar
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    Fanelli, G.M., D. Bohn and S. Reilly. Renal urate transport in the chimpanzee. Amer. J. Physiol. 220:613–620, 1971.PubMedGoogle Scholar
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    Boner, G. and T. H. Steele. Relationship of urate and p amino hippurate secretion in man. Amer. J. Physiol. 225:100–104, 1973.PubMedGoogle Scholar
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    Koch-Weser, J. and E. M. Sellars. Binding of drugs to serum albumen. N. Eng. J. Med. 294:311–316, 1976.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Herbert S. Diamond
    • 1
  • Allen D. Meisel
    • 1
  1. 1.Downstate Medical CenterBrooklynUSA

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