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The Effect of Acid Loading on Renal Excretion of Uric Acid and Ammonium in Gout

  • T. Gibson
  • S. F. Hannan
  • P. J. Hatfield
  • H. A. Simmonds
  • J. S. Cameron
  • C. S. Potter
  • C. M. Crute
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)

Abstract

A defect of ammonium production associated with a relatively acid urine has been described in patients with both gout (1) and idiopathic uric acid stone formation (2).

Keywords

Uric Acid Ammonium Chloride Titratable Acid Uric Acid Stone Gout Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Gutman, A.B., and Yu, Ts’ai-Fan, “urinary Ammonium Excretion in primary Gout”, J.Clin.Invest, 44, 1474 1965PubMedCrossRefGoogle Scholar
  2. 2.
    Henneman, P.H., Wallach, S., and Dempsey, E.F., “The metabolic defect responsible for uric acid stone formation”, J. Clin. Invest. 41, 537, 1962PubMedCrossRefGoogle Scholar
  3. 3.
    Plante, G.E. , Durivage, J., and Lemieux, G., “Renal Excretion of hydrogen in primary gout”, Metabolism, 17, 377, 1968PubMedCrossRefGoogle Scholar
  4. 4.
    Swales, J.D., Kopstein, J. and Wrong, O.M., “Renal excretion of ammonia and urate production; examination of Gutman-Yu Hypothesis”. Metabolism, 21: 541 1972PubMedCrossRefGoogle Scholar
  5. 5.
    Simmonds, H.A., “A method of estimation of uric acid in urine and other body fluids” , Clin Chim. Acta. 15, 375, 1967CrossRefGoogle Scholar
  6. 6.
    Jorgensen, K., “Titrimetric determination of the net excretion of acid/base in urine”, Scand.J. Clin., Lab. Invest. 9, 287, 1957CrossRefGoogle Scholar
  7. 10.
    Metcalfe-Gibson, A., McCallum, F.M., Morrison, R.B. I., and Wrong, O.M., “Urinary excretion of hydrogen ion in patients -with uric acid calculi”, Clin. Sci. 28,325, 1965PubMedGoogle Scholar
  8. 11.
    Falls, W.F., “Comparison of urinary acidification and ammonium excretion in normal and gouty subjects” Metabolism, 21, 433, 1974.CrossRefGoogle Scholar
  9. 12.
    Vogler, V.R., and Drane, J.W., “Effect of allopurinol on urinary ammonia excretion in patients -with gout”, Metabolism, 18, 519, 1969PubMedCrossRefGoogle Scholar
  10. 13.
    Thompson, G.R., “The effect of diazoxide, potassium chloride and ammonium chloride on serum and urinary uric acid”, Arthritis Rheum. 8, 830, 1965PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • T. Gibson
    • 1
  • S. F. Hannan
    • 1
  • P. J. Hatfield
    • 1
  • H. A. Simmonds
    • 1
  • J. S. Cameron
    • 1
  • C. S. Potter
    • 1
  • C. M. Crute
    • 1
  1. 1.Arthritis Research Unit and Department of MedicineGuy’s Hospital Medical SchoolLondonUK

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