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The Metabolic Effects of Tienilic Acid, a New Diuretic with Uricosuric Properties in Man and Dog

  • Guy Lemieux
  • André Gougoux
  • Patrick Vinay
  • André Kiss
  • Gabriel Baverel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 76B)

Abstract

Tienilic acid (2,3-dichloro-4-(2-thienyl carbonyl) phenoxy-acetic acid) is a new diuretic with a chemical structure resembling that of ethacrynic acid (1). In contrast to all other diuretics in current use, tienilic acid possesses the unique property of being a potent uricosuric agent in man and mouse (1). Although its natriuretic effect is believed to take place in the cortical diluting segment of the distal nephron (2,3). the nature and site of the uricosuric effect of tienilic acid has not been established. Investigation was designed in normal man to study the metabolic effects of tienilic acid and experiments were performed in the mongrel dog, the Dalmatian coachhound, the rabbit and the chicken to clarify the nature of its uricosuric effect.

Keywords

Ethacrynic Acid Natriuretic Effect Uric Acid Excretion Tienilic Acid Urate Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Guy Lemieux
    • 1
  • André Gougoux
    • 1
  • Patrick Vinay
    • 1
  • André Kiss
    • 1
  • Gabriel Baverel
    • 1
  1. 1.Nephrology-Metabolism Division, Hôtel-Dieu Hospital and Department of MedicineUniversity of MontrealMontrealCanada

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