The Metabolic Effects of Tienilic Acid, a New Diuretic with Uricosuric Properties in Man and Dog
Tienilic acid (2,3-dichloro-4-(2-thienyl carbonyl) phenoxy-acetic acid) is a new diuretic with a chemical structure resembling that of ethacrynic acid (1). In contrast to all other diuretics in current use, tienilic acid possesses the unique property of being a potent uricosuric agent in man and mouse (1). Although its natriuretic effect is believed to take place in the cortical diluting segment of the distal nephron (2,3). the nature and site of the uricosuric effect of tienilic acid has not been established. Investigation was designed in normal man to study the metabolic effects of tienilic acid and experiments were performed in the mongrel dog, the Dalmatian coachhound, the rabbit and the chicken to clarify the nature of its uricosuric effect.
KeywordsCarbonyl Ketone Bicarbonate Purine Nism
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